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golgb1 golgin B1 [ Danio rerio (zebrafish) ]

Gene ID: 566353, updated on 9-Sep-2025
Official Symbol
golgb1provided by ZNC
Official Full Name
golgin B1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030429-9
See related
Ensembl:ENSDARG00000061951 AllianceGenome:ZFIN:ZDB-GENE-030429-9
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
giantin; sb:cb277; wu:fb47h05; wu:fb92f11
Summary
Predicted to be located in Golgi apparatus and membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in axis; floor plate; hypochord; otic placode; and polster. Used to study hyperphosphatemic familial tumoral calcinosis. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 4 NC_133179.1 (22912655..22938609, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22312990..22338944, complement)

Chromosome 4 - NC_133179.1Genomic Context describing neighboring genes Neighboring gene LLP homolog, long-term synaptic facilitation factor Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene uncharacterized LOC101884046 Neighboring gene guanylate cyclase activator 1Aa Neighboring gene origin recognition complex, subunit 5 Neighboring gene LHFPL tetraspan subfamily member 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Giantin is required for intracellular N-terminal processing of type I procollagen. Stevenson NL, et al. J Cell Biol, 2021 Jun 7. PMID 33944912, Free PMC Article
  2. Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Stevenson NL, et al. J Cell Sci, 2017 Dec 15. PMID 29093022, Free PMC Article
  3. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
  4. The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Bergen DJM, et al. Biol Open, 2017 Aug 15. PMID 28546340, Free PMC Article
  5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Golgin subfamily B member 1; golgin subfamily B member 1
Names
golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133179.1 Reference GRCz12tu Primary Assembly

    Range
    22912655..22938609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068220776.1 → XP_068076877.1  golgin subfamily B member 1 isoform X2

    UniProtKB/TrEMBL
    A0AB32TQ84
    Related
    ENSDARP00000122063.2, ENSDART00000131402.3

  2. XM_005164908.5 → XP_005164965.1  golgin subfamily B member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BC86
    Conserved Domains (3) summary
    TIGR02168
    Location:1229 → 2039
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11898
    Location:2432 → 2566
    DUF3418; Domain of unknown function (DUF3418)
    pfam15350
    Location:1795 → 1881
    ETAA1; Ewing's tumour-associated antigen 1 homologue

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045103.1: Suppressed sequence

    Description
    NM_001045103.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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