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Trim17 tripartite motif-containing 17 [ Mus musculus (house mouse) ]

Gene ID: 56631, updated on 8-Dec-2022

Summary

Official Symbol
Trim17provided by MGI
Official Full Name
tripartite motif-containing 17provided by MGI
Primary source
MGI:MGI:1861440
See related
Ensembl:ENSMUSG00000036964 AllianceGenome:MGI:1861440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
terf; Rnf16
Summary
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including autophagy; innate immune response; and protein autoubiquitination. Predicted to be active in cytoplasm. Orthologous to human TRIM17 (tripartite motif containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 63.4), whole brain E14.5 (RPKM 20.0) and 20 other tissues See more
Orthologs
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Genomic context

See Trim17 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58845511..58863923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58954671..58973075)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51864 Neighboring gene H2B clustered histone 27 Neighboring gene H2B.U histone 1, pseudogene Neighboring gene H2A clustered histone 25 Neighboring gene H3.4 histone, cluster member Neighboring gene tripartite motif-containing 11 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM17
Names
RING-type E3 ubiquitin transferase TRIM17
ring finger protein 16
tripartite motif protein 17
tripartite motif protein TRIM17
tripartite motif-containing protein 17
NP_112449.1
XP_006533874.1
XP_006533875.1
XP_011247459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031172.3NP_112449.1  E3 ubiquitin-protein ligase TRIM17

    See identical proteins and their annotated locations for NP_112449.1

    Status: VALIDATED

    Source sequence(s)
    AL662809, BC055112
    Consensus CDS
    CCDS24756.1
    UniProtKB/Swiss-Prot
    Q7TPM3, Q99PP8
    Related
    ENSMUSP00000074639.7, ENSMUST00000075141.7
    Conserved Domains (4) summary
    PTZ00121
    Location:64271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:1366
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58845511..58863923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249157.4XP_011247459.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011247459.1

    UniProtKB/Swiss-Prot
    Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:1366
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_006533811.4XP_006533874.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006533874.1

    UniProtKB/Swiss-Prot
    Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:1366
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. XM_006533812.5XP_006533875.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006533875.1

    UniProtKB/Swiss-Prot
    Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:1366
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain