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zbtb10 zinc finger and BTB domain containing 10 [ Danio rerio (zebrafish) ]

Gene ID: 566269, updated on 17-Aug-2026
Official Symbol
zbtb10provided by ZNC
Official Full Name
zinc finger and BTB domain containing 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-030429-10
See related
Ensembl:ENSDARG00000077101 AllianceGenome:ZFIN:ZDB-GENE-030429-10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb299; si:dkeyp-34f6.1
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; forerunner cell group; nervous system; neural tube; and presumptive telencephalon. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See zbtb10 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 19 NC_133194.1 (34323711..34346031, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 19 NC_007130.7 (31878905..31900893, complement)

Chromosome 19 - NC_133194.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141379135 Neighboring gene hes-related family bHLH transcription factor with YRPW motif 1 Neighboring gene tumor protein D52 Neighboring gene zinc finger protein 704 Neighboring gene hippocalcin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Varshney GK, et al. Genome Res, 2013 Apr. PMID 23382537, Free PMC Article
  2. Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Wang D, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640903, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger and BTB domain-containing protein 10

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128539.2 → NP_001122011.1  zinc finger and BTB domain-containing protein 10

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000019
    UniProtKB/TrEMBL
    A0A8M1NHI8, A5PMB0
    Related
    ENSDARP00160019344.1, ENSDART00160034832.1
    Conserved Domains (5) summary
    smart00225
    Location:158 → 254
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:435 → 455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:147 → 253
    BTB; BTB/POZ domain
    pfam13465
    Location:448 → 472
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:433 → 457
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133194.1 Reference GRCz12tu Primary Assembly

    Range
    34323711..34346031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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