Clec4e C-type lectin domain family 4, member e [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4eprovided by MGI
Official Full Name: C-type lectin domain family 4, member eprovided by MGI
Primary source: MGI:MGI:1861232
See related: Ensembl:ENSMUSG00000030142 AllianceGenome:MGI:1861232
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mincle; Clecsf9
Summary: Enables glycolipid binding activity and pattern recognition receptor activity. Involved in antifungal innate immune response and positive regulation of cytokine production. Acts upstream of or within Fc-gamma receptor signaling pathway; T cell differentiation involved in immune response; and defense response to bacterium. Is active in phagocytic vesicle membrane and plasma membrane. Orthologous to human CLEC4E (C-type lectin domain family 4 member E). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 58.35 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (123258748..123266830, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (123281789..123289871, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mincle receptor in macrophage and neutrophil contributes to the unresolved inflammation during the transition from acute kidney injury to chronic kidney disease.
Title: Mincle receptor in macrophage and neutrophil contributes to the unresolved inflammation during the transition from acute kidney injury to chronic kidney disease.
Mincle-GSDMD-mediated release of IL-1beta small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.
Title: Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity.
Title: IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity.
A mechanism of self-lipid endocytosis mediated by the receptor Mincle.
Title: A mechanism of self-lipid endocytosis mediated by the receptor Mincle.
Mice Dually Disrupted for Nod2 and Mincle Manifest Early Bacteriological Control but Late Susceptibility During Mycobacterium tuberculosis Infection.
Title: Mice Dually Disrupted for Nod2 and Mincle Manifest Early Bacteriological Control but Late Susceptibility During Mycobacterium tuberculosis Infection.
SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury.
Title: SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury.
Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin.
Title: Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin.
Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses.
Title: Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses.
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
Title: Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.
Title: S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C86253 (e-PCR)
- UniSTS:159567

RH127282 (e-PCR)
- UniSTS:209815

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables glycolipid binding	IPI Inferred from Physical Interaction more info	PubMed
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Fc-gamma receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in phagocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 4 member E

Names: C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9; C-type lectin, superfamily member 9; macrophage-inducible C-type lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019948.2 → NP_064332.1 C-type lectin domain family 4 member E

See identical proteins and their annotated locations for NP_064332.1

Status: PROVISIONAL

Source sequence(s)

AC124563

Consensus CDS

CCDS20514.1

UniProtKB/Swiss-Prot

Q9R0Q8

UniProtKB/TrEMBL

H3BJQ5, Q4FK29

Related

ENSMUSP00000032239.5, ENSMUST00000032239.11

Conserved Domains (1) summary

cd03590
Location:80 → 207

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

123258748..123266830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321688.2 → XP_017177177.1 C-type lectin domain family 4 member E isoform X1

UniProtKB/TrEMBL

Q3U271

Conserved Domains (1) summary

cd03590
Location:37 → 164

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)