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gas2l3 growth arrest-specific 2 like 3 [ Danio rerio (zebrafish) ]

Gene ID: 566151, updated on 8-Feb-2025

Summary

Official Symbol
gas2l3provided by ZNC
Official Full Name
growth arrest-specific 2 like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2560
See related
Ensembl:ENSDARG00000045880 AllianceGenome:ZFIN:ZDB-GENE-030131-2560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc11d07; wu:fc11d07; si:ch211-203h15.1
Summary
Predicted to enable actin filament binding activity. Acts upstream of or within cell proliferation in hindbrain ventricular zone and ventricular system development. Located in microtubule. Part of filamentous actin. Is expressed in nervous system and neural tube. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See gas2l3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1686621..1720648, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1837308..1871335, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene SR-related CTD-associated factor 11 Neighboring gene AT-rich interactive domain 2 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GAS2-like protein 3
Names
gas2l3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045098.1NP_001038563.1  GAS2-like protein 3

    See identical proteins and their annotated locations for NP_001038563.1

    Status: PROVISIONAL

    Source sequence(s)
    CR847994
    UniProtKB/TrEMBL
    A0A8M2BBM5, M9PL18, Q1L8E6
    Related
    ENSDARP00000094260.4, ENSDART00000103484.5
    Conserved Domains (3) summary
    cd00014
    Location:55170
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:228284
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl26464
    Location:315528
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    1686621..1720648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475058.2XP_021330733.1  GAS2-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBM5, M9PL18, Q1L8E6
    Conserved Domains (3) summary
    cd00014
    Location:55170
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:228284
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl26464
    Location:315528
    Atrophin-1; Atrophin-1 family
  2. XM_068219695.1XP_068075796.1  GAS2-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBM5, M9PL18, Q1L8E6