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Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 56613, updated on 17-Nov-2020

Summary

Official Symbol
Rps6ka4provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 4provided by MGI
Primary source
MGI:MGI:1930076
See related
Ensembl:ENSMUSG00000024952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSK; 90kD; Msk2; 90kDa; mMSK2; AI848992; 1110069D02Rik
Expression
Ubiquitous expression in duodenum adult (RPKM 18.4), adrenal adult (RPKM 18.2) and 28 other tissues See more
Orthologs

Genomic context

See Rps6ka4 in Genome Data Viewer
Location:
19; 19 A
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6806573..6819513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6829084..6842145, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6903574..6915091, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32245 Neighboring gene high mobility group box 1, pseudogene 4 Neighboring gene microRNA 5046 Neighboring gene coiled-coil domain containing 88B Neighboring gene uncharacterized LOC118568401

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone H3-S10 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-S28 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-4
Names
90 kDa ribosomal protein S6 kinase 4
RLSK
RSK-like protein kinase
S6K-alpha-4
mitogen- and stress-activated protein kinase-2
nuclear mitogen- and stress-activated protein kinase 2
ribosomal protein S6 kinase, 90kD, polypeptide 4
NP_064308.2
XP_017173750.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019924.2NP_064308.2  ribosomal protein S6 kinase alpha-4

    See identical proteins and their annotated locations for NP_064308.2

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK089467, BF465098, BP759267, CF616720, CJ065157
    Consensus CDS
    CCDS37899.1
    UniProtKB/Swiss-Prot
    Q9Z2B9
    Related
    ENSMUSP00000025903.5, ENSMUST00000025903.5
    Conserved Domains (3) summary
    smart00220
    Location:33301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05614
    Location:32364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cd14180
    Location:404714
    STKc_MSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6806573..6819513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318261.3XP_017173750.1  ribosomal protein S6 kinase alpha-4 isoform X1

RNA

  1. XR_004940158.1 RNA Sequence

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