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Anxa2 annexin A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56611, updated on 22-Aug-2021

Summary

Official Symbol
Anxa2provided by RGD
Official Full Name
annexin A2provided by RGD
Primary source
RGD:621170
See related
Ensembl:ENSRNOG00000010362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ANX2
Summary
a plasminogen receptor; may be involved in cellular transformation [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 1285.6), Heart (RPKM 657.8) and 9 other tissues See more
Orthologs
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Genomic context

See Anxa2 in Genome Data Viewer
Location:
8q24
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70105268..70141663)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (75687134..75723589)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene RAR-related orphan receptor A Neighboring gene uncharacterized LOC120094342 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene uncharacterized LOC103693133 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding TAS
Traceable Author Statement
more info
PubMed 
enables bone sialoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in body fluid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane raft assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoclast development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vacuole organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fibrinolysis TAS
Traceable Author Statement
more info
PubMed 
involved_in response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vesicle budding from membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AnxA2-p11 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PCSK9-AnxA2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in macropinosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
annexin A2
Names
PAP-IV
annexin-2
calpactin I heavy chain
calpactin-1 heavy chain
chromobindin-8
lipocortin II
p36
placental anticoagulant protein IV
protein I

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019905.1NP_063970.1  annexin A2

    See identical proteins and their annotated locations for NP_063970.1

    Status: PROVISIONAL

    Source sequence(s)
    X66871
    UniProtKB/Swiss-Prot
    Q07936
    Related
    ENSRNOP00000038428.5, ENSRNOT00000038677.5
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    70105268..70141663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082021.1XP_038937949.1  annexin A2 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
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