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ERO1B endoplasmic reticulum oxidoreductase 1 beta [ Homo sapiens (human) ]

Gene ID: 56605, updated on 5-Aug-2022

Summary

Official Symbol
ERO1Bprovided by HGNC
Official Full Name
endoplasmic reticulum oxidoreductase 1 betaprovided by HGNC
Primary source
HGNC:HGNC:14355
See related
Ensembl:ENSG00000086619 MIM:615437; AllianceGenome:HGNC:14355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERO1LB; Ero1beta
Summary
Enables thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach (RPKM 19.2), thyroid (RPKM 16.8) and 25 other tissues See more
Orthologs
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Genomic context

See ERO1B in Genome Data Viewer
Location:
1q42.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236215101..236281958, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235617345..235684232, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236378401..236445258, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot MSTM2 Neighboring gene G protein-coupled receptor 137B Neighboring gene uncharacterized LOC124904561 Neighboring gene uncharacterized LOC124904562 Neighboring gene RNA, U2 small nuclear 70, pseudogene Neighboring gene FKBP prolyl isomerase 3 pseudogene Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11003, DKFZp779C1042, DKFZp779I0141

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ERO1-like protein beta
Names
ERO1-L-beta
ERO1-like beta
endoplasmic oxidoreductin-1-like protein B
endoplasmic reticulum oxidoreductase beta
endoplasmic reticulum oxidoreductin-1-like protein B
oxidoreductin-1-L-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019891.4NP_063944.3  ERO1-like protein beta precursor

    See identical proteins and their annotated locations for NP_063944.3

    Status: VALIDATED

    Source sequence(s)
    AL139162, AL450309, BC044573, BG723126, CR749523
    Consensus CDS
    CCDS31064.1
    UniProtKB/Swiss-Prot
    Q86YB8, Q9NR62
    Related
    ENSP00000346635.5, ENST00000354619.10
    Conserved Domains (1) summary
    pfam04137
    Location:56454
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    236215101..236281958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    235617345..235684232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)