Format

Send to:

Choose Destination

adam10a ADAM metallopeptidase domain 10a [ Danio rerio (zebrafish) ]

Gene ID: 566044, updated on 17-Nov-2020

Summary

Official Symbol
adam10aprovided by ZNC
Official Full Name
ADAM metallopeptidase domain 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040917-2
See related
Ensembl:ENSDARG00000053468
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
adam; adam10; wu:fc03d12
Orthologs

Genomic context

See adam10a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30409070..30492045, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30137916..30220894, complement)
103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (31745578..31828547, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene aquaporin 9b Neighboring gene lipase, hepatic a Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene SAFB-like, transcription modulator Neighboring gene ring finger protein 111

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain 10a
NP_001152786.1
XP_005168953.1
XP_005168954.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159314.1NP_001152786.1  disintegrin and metalloproteinase domain-containing protein 10 precursor

    Status: PROVISIONAL

    Source sequence(s)
    AL935053, BX957301
    Related
    ENSDARP00000141214.2, ENSDART00000162705.2
    Conserved Domains (4) summary
    smart00050
    Location:467547
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:221460
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:49146
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:241446
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    30409070..30492045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168897.4XP_005168954.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    F1RA88
    Related
    ENSDARP00000090413.6, ENSDART00000099639.8
    Conserved Domains (4) summary
    smart00050
    Location:472558
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:226465
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:54151
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:246451
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
  2. XM_005168896.4XP_005168953.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A1D5NT24
    Related
    ENSDARP00000142998.1, ENSDART00000173954.2
    Conserved Domains (4) summary
    smart00050
    Location:473559
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:227466
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:54151
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:247452
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
Support Center