notum2 notum pectinacetylesterase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: notum2provided by ZNC
Official Full Name: notum pectinacetylesterase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-120215-77
See related: Ensembl:ENSDARG00000088411 AllianceGenome:ZFIN:ZDB-GENE-120215-77
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-3d18.6
Summary: Predicted to enable palmitoleyl hydrolase activity. Acts upstream of or within motor neuron axon guidance. Predicted to be located in extracellular region. Is expressed in female organism; horizontal myoseptum; muscle pioneer; slow muscle cell; and trunk musculature. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (11903292..11922584, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10944725..10964021, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work demonstrates an unexpected role for a Notum homolog in regulating growth cone migration, separate from the well established functions of other Notum homologs in Wnt signaling.
Title: Notum homolog plays a novel role in primary motor innervation.
The data showed that zebrafish homolog Notum contributes to a self-regulatory loop that restricts Wnt/beta-catenin signaling. Notum did not interact with Glypican 4, an essential component of the Wnt/planar cell-polarity pathway.
Title: A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoleyl hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleyl hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein depalmitoleylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxylesterase notum2

Names: protein notum homolog

NP_001340801.1

EC 3.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353872.1 → NP_001340801.1 carboxylesterase notum2 precursor

Status: VALIDATED

Source sequence(s)

JBMGRA010000006

UniProtKB/Swiss-Prot

E7F0Z8

UniProtKB/TrEMBL

A0AB13A6U2

Related

ENSDARP00000125786.1, ENSDART00000151102.2

Conserved Domains (1) summary

pfam03283
Location:79 → 418

PAE; Pectinacetylesterase