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nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [ Danio rerio (zebrafish) ]

Gene ID: 565756, updated on 7-Apr-2025

Summary

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Official Symbol
nfkb1provided by ZNC
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-121204-3
See related
Ensembl:ENSDARG00000105261 AllianceGenome:ZFIN:ZDB-GENE-121204-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p50
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; epithelium development; and nervous system development. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of NF-kappaB p50/p65 complex. Is expressed in brain and retina. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency 12; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Genomic context

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See nfkb1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (49811942..49859739, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (50610043..50657835, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487627 Neighboring gene synaptopodin Neighboring gene tetraspanin 17 Neighboring gene ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Ko YA, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575649, Free PMC Article
  2. Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model. Jaiswal Y, et al. Brain Sci, 2020 Aug 11. PMID 32796575, Free PMC Article
  3. Adult zebrafish as an in vivo drug testing model for ethanol induced acute hepatic injury. Park KH, et al. Biomed Pharmacother, 2020 Dec. PMID 33035832, Free PMC Article
  4. Morpho-functional remodelling of the adult zebrafish (Danio rerio) heart in response to waterborne angiotensin II exposure. Filice M, et al. Gen Comp Endocrinol, 2021 Jan 15. PMID 33220301
  5. Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model. Paudel YN, et al. Front Pharmacol, 2020. PMID 33732146, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study indicate an essential role of NF-kappaB in gonadal differentiation.
    Title: Activation of NF-κB protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelium development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NF-kappaB p50/p65 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BICD family-like cargo adapter 1; nuclear factor NF-kappa-B p105 subunit
Names
NF-kB1 precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    49811942..49859739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481270.2 → XP_021336945.1  nuclear factor NF-kappa-B p105 subunit isoform X3

    UniProtKB/TrEMBL
    A0A8M9QPM1
    Conserved Domains (2) summary
    cd01177
    Location:255 → 354
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cl08275
    Location:47 → 248
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  2. XM_021481269.2 → XP_021336944.1  nuclear factor NF-kappa-B p105 subunit isoform X2

    UniProtKB/TrEMBL
    A0A8M9QGX8
    Conserved Domains (2) summary
    cd01177
    Location:260 → 359
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cl08275
    Location:52 → 253
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  3. XM_068213417.1 → XP_068069518.1  nuclear factor NF-kappa-B p105 subunit isoform X1

    UniProtKB/TrEMBL
    A0A0R4IN79, A0A8M2BHN4
    Related
    ENSDARP00000135800.1, ENSDART00000164967.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001353873.1: Suppressed sequence

    Description
    NM_001353873.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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