Vmn2r26 vomeronasal 2, receptor 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vmn2r26provided by MGI
Official Full Name: vomeronasal 2, receptor 26provided by MGI
Primary source: MGI:MGI:2678394
See related: Ensembl:ENSMUSG00000096630 AllianceGenome:MGI:2678394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V2R1; V2r1b
Summary: Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F2; 6 59.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (124001717..124038994)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (124024758..124062035)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the peptide presentation system provided by MHC molecules co-evolves with the peptide recognition systems expressed by T cells and vomeronasal sensory neurons
Title: Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled olfactory receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vomeronasal type-2 receptor 26

Names: putative pheromone receptor V2R1b; tissue-type vomeronasal neurons putative pheromone receptor V2R1; vomeronasal 2, receptor, 1b; vomeronasal receptor Vmn2r26; vomeronasal type-2 receptor 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019917.2 → NP_064301.2 vomeronasal type-2 receptor 26 precursor

See identical proteins and their annotated locations for NP_064301.2

Status: VALIDATED

Source sequence(s)

AC122868, AC147222, AY426342

Consensus CDS

CCDS20515.1

UniProtKB/Swiss-Prot

O70409, Q6TAC4

Related

ENSMUSP00000032238.4, ENSMUST00000032238.5

Conserved Domains (4) summary

cd06365
Location:38 → 511

PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam00003
Location:606 → 840

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:83 → 451

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR