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KLK10 kallikrein related peptidase 10 [ Homo sapiens (human) ]

Gene ID: 5655, updated on 14-Oct-2018

Summary

Official Symbol
KLK10provided by HGNC
Official Full Name
kallikrein related peptidase 10provided by HGNC
Primary source
HGNC:HGNC:6358
See related
Ensembl:ENSG00000129451 MIM:602673; Vega:OTTHUMG00000182916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NES1; PRSSL1
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more
Orthologs

Genomic context

See KLK10 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51012744..51020175, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51516000..51523431, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 8 Neighboring gene kallikrein related peptidase 9 Neighboring gene kallikrein related peptidase 11 Neighboring gene kallikrein related peptidase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-10
Names
breast normal epithelial cell associated serine protease
kallikrein 10 protein 1
kallikrein 10 protein 12
kallikrein 10 protein 13
kallikrein 10 protein 2
kallikrein 10 protein 3
kallikrein 10 protein 4
kallikrein 10 protein 5
kallikrein 10 protein 7
kallikrein 10 protein 8
kallikrein 10 protein 9
normal epithelial cell-specific 1
protease serine-like 1
NP_001070968.1
NP_002767.2
NP_665895.1
XP_005259118.1
XP_005259119.1
XP_006723350.1
XP_006723352.1
XP_016882482.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077500.1NP_001070968.1  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_001070968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AY561635, BM830577, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    O43240
    Related
    ENSP00000375681.1, ENST00000391805.5
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_002776.4NP_002767.2  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_002767.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AY561635, BC002710, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    O43240
    Related
    ENSP00000311746.2, OTTHUMP00000270512, ENST00000309958.7, OTTHUMT00000464337
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_145888.2NP_665895.1  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_665895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AF024605, AY561635, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    O43240
    Related
    ENSP00000351640.2, OTTHUMP00000270511, ENST00000358789.7, OTTHUMT00000464336
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51012744..51020175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723289.3XP_006723352.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_006723352.1

    UniProtKB/Swiss-Prot
    O43240
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_005259061.3XP_005259118.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_005259118.1

    UniProtKB/Swiss-Prot
    O43240
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006723287.4XP_006723350.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_006723350.1

    UniProtKB/Swiss-Prot
    O43240
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_005259062.3XP_005259119.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_005259119.1

    UniProtKB/Swiss-Prot
    O43240
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_017026993.2XP_016882482.1  kallikrein-10 isoform X1

    UniProtKB/Swiss-Prot
    O43240
    Conserved Domains (2) summary
    smart00020
    Location:49269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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