U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hdac6 histone deacetylase 6 [ Danio rerio (zebrafish) ]

Gene ID: 565482, updated on 5-Jul-2025
Official Symbol
hdac6provided by ZNC
Official Full Name
histone deacetylase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3232
See related
Ensembl:ENSDARG00000008384 AllianceGenome:ZFIN:ZDB-GENE-030131-3232
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc31d02
Summary
Enables potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of tubulin deacetylation; and swimming behavior. Predicted to be located in several cellular components, including centrosome; dendrite; and perikaryon. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia and polycystic liver disease 1. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See hdac6 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (8927983..8979327, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7393435..7444466, complement)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene ssu-2 homolog, related sequence 1 Neighboring gene selenoprotein H Neighboring gene histone H3-like centromeric protein A Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor, like Neighboring gene LHFPL tetraspan subfamily member 4b Neighboring gene GATA binding protein 1b Neighboring gene cyclin dependent kinase 20

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia. Fischer F, et al. J Med Chem, 2024 Dec 12. PMID 39602240
  2. Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Hai Y, et al. Nat Chem Biol, 2016 Sep. PMID 27454933, Free PMC Article
  3. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Porter NJ, et al. Proc Natl Acad Sci U S A, 2017 Dec 19. PMID 29203661, Free PMC Article
  4. Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors. Sellmer A, et al. J Med Chem, 2018 Apr 26. PMID 29589441
  5. Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Mackwitz MKW, et al. Org Lett, 2018 Jun 1. PMID 29790770, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
    Title: Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
  2. Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.
    Title: Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.
  3. HDAC6 inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors.
    Title: HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables acetylspermidine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion localization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein deacetylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of biological quality IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tubulin deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein deacetylase HDAC6
XP_009302026.1
XP_009302027.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    8927983..8979327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303752.3 → XP_009302027.1  protein deacetylase HDAC6

    See identical proteins and their annotated locations for XP_009302027.1

    UniProtKB/TrEMBL
    A0A8M3BBK8, A7YT55, F8W4B7
    Related
    ENSDARP00000153983.1, ENSDART00000180659.1
    Conserved Domains (3) summary
    cd10003
    Location:448 → 798
    HDAC6-dom2; Histone deacetylase 6, domain 2
    cd11682
    Location:76 → 412
    HDAC6-dom1; Histone deacetylase 6, domain 1
    pfam02148
    Location:999 → 1061
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_009303751.4 → XP_009302026.1  protein deacetylase HDAC6

    See identical proteins and their annotated locations for XP_009302026.1

    UniProtKB/TrEMBL
    A0A8M3BBK8, A7YT55, F8W4B7
    Related
    ENSDARP00000124246.1, ENSDART00000148993.3
    Conserved Domains (3) summary
    cd10003
    Location:448 → 798
    HDAC6-dom2; Histone deacetylase 6, domain 2
    cd11682
    Location:76 → 412
    HDAC6-dom1; Histone deacetylase 6, domain 1
    pfam02148
    Location:999 → 1061
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.