CHST7 carbohydrate sulfotransferase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHST7provided by HGNC
Official Full Name: carbohydrate sulfotransferase 7provided by HGNC
Primary source: HGNC:HGNC:13817
See related: Ensembl:ENSG00000147119 MIM:300375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GST-5; C6ST-2
Summary: This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]
Expression: Broad expression in spleen (RPKM 5.5), fat (RPKM 5.1) and 22 other tissues See more
Orthologs: mouse all

Genomic context

Location:: Xp11.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	X	NC_000023.11 (46573765..46598496)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (46433192..46457838)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHST7 methylation in white blood cells is positively associated with CRC risk, especially in females, and may potentially serve as a blood-based predictive biomarker for CRC risk.
Title: CHST7 Gene Methylation and Sex-Specific Effects on Colorectal Cancer Risk.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the CHST7 gene: The CHST7 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 266 organisms have orthologs with human gene CHST7
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
N-acetylglucosamine 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
N-acetylglucosamine 6-O-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
chondroitin 6-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
chondroitin 6-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
N-acetylglucosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
chondroitin sulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
chondroitin sulfate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
chondroitin sulfate biosynthetic process	TAS Traceable Author Statement more info
polysaccharide metabolic process	TAS Traceable Author Statement more info	PubMed
sulfur compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi membrane	TAS Traceable Author Statement more info
integral component of membrane	NAS Non-traceable Author Statement more info	PubMed
integral component of membrane	TAS Traceable Author Statement more info	PubMed
trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: carbohydrate sulfotransferase 7

Names: N-acetylglucosamine 6-O-sulfotransferase 4; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7; chondroitin 6-sulfotransferase-2; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; glcNAc6ST-4; gn6st-4

NP_063939.2

EC 2.8.2.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.