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CHST7 carbohydrate sulfotransferase 7 [ Homo sapiens (human) ]

Gene ID: 56548, updated on 11-Sep-2019

Summary

Official Symbol
CHST7provided by HGNC
Official Full Name
carbohydrate sulfotransferase 7provided by HGNC
Primary source
HGNC:HGNC:13817
See related
Ensembl:ENSG00000147119 MIM:300375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST-5; C6ST-2
Summary
This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]
Expression
Broad expression in spleen (RPKM 5.5), fat (RPKM 5.1) and 22 other tissues See more
Orthologs

Genomic context

See CHST7 in Genome Data Viewer
Location:
Xp11.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (46573765..46598496)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (46433192..46457838)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ZNF674 antisense RNA 1 (head to head) Neighboring gene marker of proliferation Ki-67 pseudogene 1 Neighboring gene solute carrier family 9 member A7 Neighboring gene phosphoglycerate mutase 1 pseudogene 7 Neighboring gene Y-box binding protein 1 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KRBOX4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
polysaccharide metabolic process TAS
Traceable Author Statement
more info
PubMed 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 7
Names
N-acetylglucosamine 6-O-sulfotransferase 4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chondroitin 6-sulfotransferase-2
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5
glcNAc6ST-4
gn6st-4
NP_063939.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029799.1 RefSeqGene

    Range
    5009..29740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019886.4NP_063939.2  carbohydrate sulfotransferase 7 precursor

    See identical proteins and their annotated locations for NP_063939.2

    Status: REVIEWED

    Source sequence(s)
    AB037187, BC045537, BP250418, DA155923, DA277492
    Consensus CDS
    CCDS14268.1
    UniProtKB/Swiss-Prot
    Q9NS84
    Related
    ENSP00000276055.3, ENST00000276055.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    46573765..46598496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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