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CHST7 carbohydrate sulfotransferase 7 [ Homo sapiens (human) ]

Gene ID: 56548, updated on 11-Jun-2025
Official Symbol
CHST7provided by HGNC
Official Full Name
carbohydrate sulfotransferase 7provided by HGNC
Primary source
HGNC:HGNC:13817
See related
Ensembl:ENSG00000147119 MIM:300375; AllianceGenome:HGNC:13817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST-5; C6ST-2
Summary
This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]
Expression
Broad expression in spleen (RPKM 5.5), fat (RPKM 5.1) and 22 other tissues See more
Orthologs
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See CHST7 in Genome Data Viewer
Location:
Xp11.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (46573765..46598496)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (45980734..46005466)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (46433200..46457931)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:46404230-46405429 Neighboring gene ZNF674 antisense RNA 1 (head to head) Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:46411040-46411938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20791 Neighboring gene marker of proliferation Ki-67 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:46447043-46447647 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:46447648-46448251 Neighboring gene uncharacterized LOC124905182 Neighboring gene solute carrier family 9 member A7 Neighboring gene phosphoglycerate mutase 1 pseudogene 7

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: KRBOX4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 6-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin 6-sulfotransferase activity TAS
Traceable Author Statement
more info
 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
carbohydrate sulfotransferase 7
Names
N-acetylglucosamine 6-O-sulfotransferase 4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chondroitin 6-sulfotransferase-2
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5
glcNAc6ST-4
gn6st-4
NP_063939.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029799.1 RefSeqGene

    Range
    5009..29740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019886.4NP_063939.2  carbohydrate sulfotransferase 7

    See identical proteins and their annotated locations for NP_063939.2

    Status: REVIEWED

    Source sequence(s)
    AB037187, BC045537, BP250418, DA155923, DA277492
    Consensus CDS
    CCDS14268.1
    UniProtKB/Swiss-Prot
    O75667, Q9NS84
    Related
    ENSP00000276055.3, ENST00000276055.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    46573765..46598496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    45980734..46005466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)