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Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 56543, updated on 8-Jan-2023

Summary

Official Symbol
Kcnd3provided by MGI
Official Full Name
potassium voltage-gated channel, Shal-related family, member 3provided by MGI
Primary source
MGI:MGI:1928743
See related
Ensembl:ENSMUSG00000040896 AllianceGenome:MGI:1928743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kncd3; Kv4.3
Summary
Enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization. Acts upstream of or within cardiac conduction; cardiac muscle cell action potential involved in contraction; and potassium ion export across plasma membrane. Located in membrane. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in heart and heart ventricle. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 8.1), cerebellum adult (RPKM 6.3) and 17 other tissues See more
Orthologs
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Genomic context

See Kcnd3 in Genome Data Viewer
Location:
3; 3 F2.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105359206..105581318)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105451890..105674002)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40118 Neighboring gene predicted gene, 34837 Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene DEAD box helicase 20 Neighboring gene inka box actin regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily D member 3
Names
potassium channel Kv4.3L
potassium channel Kv4.3M
voltage-gated potassium channel subunit Kv4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039347.2NP_001034436.1  potassium voltage-gated channel subfamily D member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001034436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC123041, AC123847, AC139316
    Consensus CDS
    CCDS17708.1
    UniProtKB/Swiss-Prot
    Q9Z0V1
    UniProtKB/TrEMBL
    A0A8C6GI45, Q3UH54
    Related
    ENSMUSP00000096357.4, ENSMUST00000098761.10
    Conserved Domains (6) summary
    smart00225
    Location:42139
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:217412
    Ion_trans; Ion transport protein
    pfam02214
    Location:42131
    BTB_2; BTB/POZ domain
    pfam07885
    Location:328408
    Ion_trans_2; Ion channel
    pfam11601
    Location:328
    Shal-type; Shal-type voltage-gated potassium channels
    pfam11879
    Location:442544
    DUF3399; Domain of unknown function (DUF3399)
  2. NM_019931.2NP_064315.1  potassium voltage-gated channel subfamily D member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_064315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123041, AC123847, AC139316
    Consensus CDS
    CCDS17709.1
    UniProtKB/Swiss-Prot
    Q9Z0V0, Q9Z0V1
    UniProtKB/TrEMBL
    A0A8C6GI39, B2RUE0
    Related
    ENSMUSP00000078169.5, ENSMUST00000079169.5
    Conserved Domains (3) summary
    cd18419
    Location:6143
    BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
    pfam00520
    Location:182412
    Ion_trans; Ion transport protein
    pfam11879
    Location:442563
    DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105359206..105581318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163174.1XP_036019067.1  potassium voltage-gated channel subfamily D member 3 isoform X2

    Conserved Domains (2) summary
    cd18419
    Location:6143
    BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
    pfam00520
    Location:186369
    Ion_trans; Ion transport protein
  2. XM_030252699.2XP_030108559.1  potassium voltage-gated channel subfamily D member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z0V0
    UniProtKB/TrEMBL
    A0A8C6GI39, B2RUE0
    Conserved Domains (3) summary
    cd18419
    Location:6143
    BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
    pfam00520
    Location:182412
    Ion_trans; Ion transport protein
    pfam11879
    Location:442563
    DUF3399; Domain of unknown function (DUF3399)