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Ripk3 receptor-interacting serine-threonine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 56532, updated on 24-Sep-2024

Summary

Official Symbol
Ripk3provided by MGI
Official Full Name
receptor-interacting serine-threonine kinase 3provided by MGI
Primary source
MGI:MGI:2154952
See related
Ensembl:ENSMUSG00000022221 AllianceGenome:MGI:2154952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rip3; 2610528K09Rik
Summary
Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Mprip (Gene ID: 26936) and Ripk3 (Gene ID: 56532) share the RIP3 symbol/alias in common. RIP3 is a widely used alternative name for Ripk3 (Gene ID: 56532), which can be confused with Mprip (Gene ID: 26936), which also uses RIP3 as an alternative name. [05 Mar 2019]
Expression
Broad expression in large intestine adult (RPKM 17.7), thymus adult (RPKM 10.3) and 18 other tissues See more
Orthologs
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Genomic context

See Ripk3 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56022452..56026314, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55784995..55788857, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor 1 Neighboring gene adenylate cyclase 4 Neighboring gene predicted gene, 32092 Neighboring gene STARR-positive B cell enhancer mm9_chr14:56441298-56441599 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Neighboring gene STARR-seq mESC enhancer starr_36783 Neighboring gene NYN domain and retroviral integrase containing Neighboring gene STARR-positive B cell enhancer ABC_E7318

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of necroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph node development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of T cell mediated cytotoxicity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of activated T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of activation-induced cell death of T cells IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of adaptive immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 3
Names
RIP-3
RIP-like protein kinase 3
mRIP3
receptor interacting protein 3
NP_001157579.1
NP_001157580.1
NP_064339.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164107.1NP_001157579.1  receptor-interacting serine/threonine-protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001157579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, compared to variant 1.This difference results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variant 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AA270784, AC098877, AK012177, BF658559
    Consensus CDS
    CCDS49499.1
    UniProtKB/TrEMBL
    E9PZP3
    Related
    ENSMUSP00000137278.2, ENSMUST00000178399.3
    Conserved Domains (2) summary
    pfam12721
    Location:346393
    RHIM; RIP homotypic interaction motif
    cl21453
    Location:1220
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001164108.1NP_001157580.1  receptor-interacting serine/threonine-protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001157580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1.This difference results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variant 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AA270784, AC098877, AK012177, BF658559, BY206463
    Consensus CDS
    CCDS49499.1
    UniProtKB/TrEMBL
    E9PZP3
    Related
    ENSMUSP00000126306.2, ENSMUST00000168716.8
    Conserved Domains (2) summary
    pfam12721
    Location:346393
    RHIM; RIP homotypic interaction motif
    cl21453
    Location:1220
    PKc_like; Protein Kinases, catalytic domain
  3. NM_019955.2NP_064339.2  receptor-interacting serine/threonine-protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_064339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA270784, AC098877, AK012177, BF658559, BY209344
    Consensus CDS
    CCDS27131.1
    UniProtKB/Swiss-Prot
    G3X8V8, Q3U3Z9, Q8K2Y2, Q9QZL0
    Related
    ENSMUSP00000022830.7, ENSMUST00000022830.14
    Conserved Domains (3) summary
    pfam00069
    Location:24284
    Pkinase; Protein kinase domain
    pfam12721
    Location:410457
    RHIM; RIP homotypic interaction motif
    cl21453
    Location:28284
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56022452..56026314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)