U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Septin6 septin 6 [ Mus musculus (house mouse) ]

Gene ID: 56526, updated on 9-May-2024

Summary

Official Symbol
Septin6provided by MGI
Official Full Name
septin 6provided by MGI
Primary source
MGI:MGI:1888939
See related
Ensembl:ENSMUSG00000050379 AllianceGenome:MGI:1888939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sep6; Sept6; mKIAA0128; 2810035H17Rik; C920001C06Rik
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cilium assembly; and cytoskeleton-dependent cytokinesis. Predicted to act upstream of or within cell differentiation; cell division; and spermatogenesis. Located in several cellular components, including cleavage furrow; septin cytoskeleton; and synaptic vesicle. Part of septin complex. Is expressed in alimentary system; central nervous system; eye; metanephros; and thymus. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 14.7), CNS E18 (RPKM 10.5) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Septin6 in Genome Data Viewer
Location:
X A3.3; X 21.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36174925..36253711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36911272..36990036, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2A Neighboring gene STARR-positive B cell enhancer ABC_E11047 Neighboring gene NF-kappaB repressing factor Neighboring gene predicted gene 15008 Neighboring gene STARR-seq mESC enhancer starr_47007 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34520906-34521122 Neighboring gene sosondowah ankyrin repeat domain family member D Neighboring gene predicted gene, 26099

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0128

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in septin collar IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in septin ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177323.2NP_001170794.1  septin-6 isoform 3

    See identical proteins and their annotated locations for NP_001170794.1

    Status: VALIDATED

    Source sequence(s)
    AK048455, BM245544, BY776992
    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (2) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:20372
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  2. NM_001177324.1NP_001170795.1  septin-6 isoform 1

    See identical proteins and their annotated locations for NP_001170795.1

    Status: VALIDATED

    Source sequence(s)
    AK012858, AK162755, AK172894, BY776992, CJ312154
    Consensus CDS
    CCDS53051.1
    UniProtKB/Swiss-Prot
    A2A3V9, A2A3W0, Q3TRH9, Q3TUA2, Q542H3, Q6A0C4, Q8C2L2, Q8C848, Q91XH2, Q9CZ94, Q9R1T4
    UniProtKB/TrEMBL
    Q3UUU4
    Related
    ENSMUSP00000110894.4, ENSMUST00000115239.10
    Conserved Domains (2) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21373
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  3. NM_001253706.1NP_001240635.1  septin-6 isoform 4

    See identical proteins and their annotated locations for NP_001240635.1

    Status: VALIDATED

    Source sequence(s)
    AK172894, BY776992, CN459422
    Consensus CDS
    CCDS57749.1
    UniProtKB/TrEMBL
    Q3UUU4
    Related
    ENSMUSP00000054034.5, ENSMUST00000053456.11
    Conserved Domains (1) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
  4. NM_001359140.1NP_001346069.1  septin-6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL450399
    Consensus CDS
    CCDS57749.1
    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
  5. NM_001359141.1NP_001346070.1  septin-6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL450399
    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39298
    CDC_Septin; CDC/Septin GTPase family
  6. NM_001359142.1NP_001346071.1  septin-6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL450399
    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39298
    CDC_Septin; CDC/Septin GTPase family
  7. NM_019942.5NP_064326.2  septin-6 isoform 2

    See identical proteins and their annotated locations for NP_064326.2

    Status: VALIDATED

    Source sequence(s)
    AK048455, AK160884, BM245544, BY776992
    Consensus CDS
    CCDS30066.1
    UniProtKB/TrEMBL
    Q3UUU4
    Related
    ENSMUSP00000062014.8, ENSMUST00000060474.14
    Conserved Domains (2) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21373
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36174925..36253711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162051.1XP_036017944.1  septin-6 isoform X4

    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39298
    CDC_Septin; CDC/Septin GTPase family
  2. XM_030251429.2XP_030107289.1  septin-6 isoform X5

    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39298
    CDC_Septin; CDC/Septin GTPase family
  3. XM_006541388.4XP_006541451.1  septin-6 isoform X1

    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
  4. XM_006541390.4XP_006541453.1  septin-6 isoform X2

    See identical proteins and their annotated locations for XP_006541453.1

    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39307
    CDC_Septin; CDC/Septin GTPase family
  5. XM_006541391.4XP_006541454.1  septin-6 isoform X3

    UniProtKB/TrEMBL
    Q3UUU4
    Conserved Domains (1) summary
    cd01850
    Location:39298
    CDC_Septin; CDC/Septin GTPase family