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Papolb poly (A) polymerase beta (testis specific) [ Mus musculus (house mouse) ]

Gene ID: 56522, updated on 1-Mar-2024

Summary

Official Symbol
Papolbprovided by MGI
Official Full Name
poly (A) polymerase beta (testis specific)provided by MGI
Primary source
MGI:MGI:1932115
See related
Ensembl:ENSMUSG00000074817 AllianceGenome:MGI:1932115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAP; Papt; Tpap; Paplob; Plap-ps; Papola-ps
Summary
Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within RNA polyadenylation. Located in endoplasmic reticulum and nucleus. Is expressed in ductus deferens; epididymis; skin; and testis. Orthologous to human PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Papolb in Genome Data Viewer
Location:
5 G2; 5 81.53 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142513495..142515831, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142527740..142530076, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2771 Neighboring gene STARR-seq mESC enhancer starr_14747 Neighboring gene adaptor-related protein complex 5, zeta 1 subunit Neighboring gene Ras association and DIL domains Neighboring gene predicted gene, 38732 Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene predicted gene, 31274

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly(A) polymerase beta
Names
PAP-beta
polynucleotide adenylyltransferase beta
testis-specific poly(A) polymerase
NP_064327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019943.2NP_064327.1  poly(A) polymerase beta

    See identical proteins and their annotated locations for NP_064327.1

    Status: VALIDATED

    Source sequence(s)
    CAAA01187077
    Consensus CDS
    CCDS39362.1
    UniProtKB/Swiss-Prot
    Q9R1R3, Q9WVP6
    UniProtKB/TrEMBL
    A1L349
    Related
    ENSMUSP00000100595.2, ENSMUST00000099400.3
    Conserved Domains (3) summary
    PTZ00418
    Location:10569
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:367508
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22364
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142513495..142515831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)