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adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [ Danio rerio (zebrafish) ]

Gene ID: 565145, updated on 27-Mar-2024

Summary

Official Symbol
adamts1provided by ZNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070814-1
See related
Ensembl:ENSDARG00000103519 AllianceGenome:ZFIN:ZDB-GENE-070814-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in ovarian follicle. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See adamts1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (672189..681503, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (677013..689428, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein a Neighboring gene cysteine/tyrosine-rich 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 5 Neighboring gene N-6 adenine-specific DNA methyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 1
XP_021331598.1
XP_021331599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    672189..681503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475924.1XP_021331599.1  A disintegrin and metalloproteinase with thrombospondin motifs 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q2N0
    Related
    ENSDARP00000131839.2, ENSDART00000165894.2
    Conserved Domains (5) summary
    smart00209
    Location:517561
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:204410
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:29136
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:673791
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:423495
    ADAM_CR; ADAM cysteine-rich
  2. XM_021475923.1XP_021331598.1  A disintegrin and metalloproteinase with thrombospondin motifs 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PWV9
    Conserved Domains (5) summary
    smart00209
    Location:517561
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:204410
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:29136
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:673791
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:423495
    ADAM_CR; ADAM cysteine-rich