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Ruvbl1 RuvB-like AAA ATPase 1 [ Mus musculus (house mouse) ]

Gene ID: 56505, updated on 18-Apr-2024

Summary

Official Symbol
Ruvbl1provided by MGI
Official Full Name
RuvB-like AAA ATPase 1provided by MGI
Primary source
MGI:MGI:1928760
See related
Ensembl:ENSMUSG00000030079 AllianceGenome:MGI:1928760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tip49a; Pontin52; 2510009G06Rik
Summary
Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; histone acetylation; and regulation of gene expression. Predicted to act upstream of or within several processes, including DNA metabolic process; chromatin organization; and regulation of growth. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; limb; liver; maxillary process; and sensory organ. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 29.2), liver E14 (RPKM 28.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6 D1; 6 39.51 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88442391..88474548)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88465409..88497566)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57776 Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88415220-88415403 Neighboring gene predicted gene, 44264 Neighboring gene STARR-seq mESC enhancer starr_16584 Neighboring gene predicted gene, 46965 Neighboring gene SEC61 translocon subunit alpha 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of R2TP complex ISO
Inferred from Sequence Orthology
more info
 
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ruvB-like 1
Names
49 kDa TATA box-binding protein-interacting protein
49 kDa TBP-interacting protein
DNA helicase p50
Pontin 52
RuvB-like protein 1
NP_062659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019685.3NP_062659.1  ruvB-like 1

    See identical proteins and their annotated locations for NP_062659.1

    Status: VALIDATED

    Source sequence(s)
    AC153694, AF100694, AK132783
    Consensus CDS
    CCDS20336.1
    UniProtKB/Swiss-Prot
    O35753, P60122
    UniProtKB/TrEMBL
    Q3U1C2, Q3UJN2
    Related
    ENSMUSP00000032165.10, ENSMUST00000032165.16
    Conserved Domains (1) summary
    COG1224
    Location:2455
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88442391..88474548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)