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Elf4 E74 like ETS transcription factor 4 [ Mus musculus (house mouse) ]

Gene ID: 56501, updated on 27-Nov-2024

Summary

Official Symbol
Elf4provided by MGI
Official Full Name
E74 like ETS transcription factor 4provided by MGI
Primary source
MGI:MGI:1928377
See related
Ensembl:ENSMUSG00000031103 AllianceGenome:MGI:1928377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mef; Gm9907
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lymphocyte proliferation; negative regulation of cytokine production; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 29.1), spleen adult (RPKM 20.4) and 20 other tissues See more
Orthologs
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Genomic context

See Elf4 in Genome Data Viewer
Location:
X A5; X 25.67 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47499926..47552009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48411049..48463132, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530027J09 gene Neighboring gene UTP14A small subunit processome component Neighboring gene STARR-positive B cell enhancer mm9_chrX:45637714-45638015 Neighboring gene STARR-seq mESC enhancer starr_47113 Neighboring gene STARR-seq mESC enhancer starr_47114 Neighboring gene STARR-seq mESC enhancer starr_47116 Neighboring gene BCL6 co-repressor-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129343, MGC129361

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in NK T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in natural killer cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ETS-related transcription factor Elf-4
Names
E74-like factor 4 (ets domain transcription factor)
E74-like factor 4; myeloid elf-1-like factor; myeloid elf-1 like factor
myeloid elf-1-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381876.1NP_001368805.1  ETS-related transcription factor Elf-4

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL844594
    UniProtKB/Swiss-Prot
    B1AY67, Q9Z2U4
    UniProtKB/TrEMBL
    Q32MF0, Q3U2M4
    Related
    ENSMUSP00000110608.2, ENSMUST00000114958.8
    Conserved Domains (2) summary
    pfam00178
    Location:209289
    Ets; Ets-domain
    pfam12310
    Location:2103
    Elf-1_N; Transcription factor protein N terminal
  2. NM_019680.2NP_062654.2  ETS-related transcription factor Elf-4

    See identical proteins and their annotated locations for NP_062654.2

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL844594
    Consensus CDS
    CCDS30108.1
    UniProtKB/Swiss-Prot
    B1AY67, Q9Z2U4
    UniProtKB/TrEMBL
    Q32MF0, Q3U2M4
    Related
    ENSMUSP00000033429.3, ENSMUST00000033429.9
    Conserved Domains (2) summary
    pfam00178
    Location:209289
    Ets; Ets-domain
    pfam12310
    Location:2103
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47499926..47552009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541527.1XP_006541590.1  ETS-related transcription factor Elf-4 isoform X1

    See identical proteins and their annotated locations for XP_006541590.1

    UniProtKB/Swiss-Prot
    B1AY67, Q9Z2U4
    UniProtKB/TrEMBL
    Q32MF0, Q3U2M4
    Conserved Domains (2) summary
    pfam00178
    Location:209289
    Ets; Ets-domain
    pfam12310
    Location:2103
    Elf-1_N; Transcription factor protein N terminal