apbb2b amyloid beta (A4) precursor protein-binding, family B, member 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apbb2bprovided by ZNC
Official Full Name: amyloid beta (A4) precursor protein-binding, family B, member 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-73
See related: Ensembl:ENSDARG00000099995 AllianceGenome:ZFIN:ZDB-GENE-090313-73
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-201g8.2
Summary: Predicted to enable amyloid-beta binding activity and molecular adaptor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in hypural. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (21396961..21499282)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (19896288..19994951)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_688300.11 → XP_693392.8 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

A0A8M9PIS6, A0A8N7TDH9
XM_009307588.5 → XP_009305863.2 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

A0A8M3AZH4, A0AB32TFH5
XM_068221135.2 → XP_068077236.2 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

A0AB32TGL4, A0AB32TN08
XM_073950572.1 → XP_073806673.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

A0AB32TN08
XM_068221136.2 → XP_068077237.2 amyloid beta precursor protein binding family B member 2 isoform X5

UniProtKB/TrEMBL

A0AB32TRC1
XM_073950575.1 → XP_073806676.1 amyloid beta precursor protein binding family B member 2 isoform X6

UniProtKB/TrEMBL

A0AB32TRC1
XM_073950586.1 → XP_073806687.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

A0AB32TRC1
XM_073950593.1 → XP_073806694.1 amyloid beta precursor protein binding family B member 2 isoform X8