Nxt1 NTF2-related export protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxt1provided by MGI
Official Full Name: NTF2-related export protein 1provided by MGI
Primary source: MGI:MGI:1929619
See related: Ensembl:ENSMUSG00000036992 AllianceGenome:MGI:1929619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110001N02Rik
Summary: Enables small GTPase binding activity. Acts upstream of or within RNA export from nucleus and protein export from nucleus. Part of nuclear pore. Is expressed in several structures, including alimentary system; brain; sensory organ; spinal cord; and tail dorsal root ganglion. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 59.4), CNS E11.5 (RPKM 25.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 G3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148514535..148517946)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148672615..148676026)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
Title: Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element
Title: Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nxt1 (e-PCR), detects polymorphism
- UniSTS:479184

Homology

Homologs of the Nxt1 gene: The Nxt1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, fruit fly, and mosquito.
Orthologs from Annotation Pipeline: 189 organisms have orthologs with human gene Nxt1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NTF2-related export protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110159.1 → NP_001103629.1 NTF2-related export protein 1

See identical proteins and their annotated locations for NP_001103629.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AL928638, AW908959, BY091455, CJ186513

Consensus CDS

CCDS16840.1

UniProtKB/Swiss-Prot

Q9D1P7, Q9QZV9

UniProtKB/TrEMBL

A0A6P5P507, A0A8C6MPN1

Related

ENSMUSP00000105587.2, ENSMUST00000109961.8

Conserved Domains (1) summary

cd00780
Location:12 → 137

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_019761.6 → NP_062735.4 NTF2-related export protein 1

See identical proteins and their annotated locations for NP_062735.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AK003254, AL928638, AW908959, CJ186513

Consensus CDS

CCDS16840.1

UniProtKB/Swiss-Prot

Q9D1P7, Q9QZV9

UniProtKB/TrEMBL

A0A6P5P507, A0A8C6MPN1

Related

ENSMUSP00000038329.4, ENSMUST00000047177.4

Conserved Domains (1) summary

cd00780
Location:12 → 137

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...