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Gabarap gamma-aminobutyric acid receptor associated protein [ Mus musculus (house mouse) ]

Gene ID: 56486, updated on 11-Apr-2024

Summary

Official Symbol
Gabarapprovided by MGI
Official Full Name
gamma-aminobutyric acid receptor associated proteinprovided by MGI
Primary source
MGI:MGI:1861742
See related
Ensembl:ENSMUSG00000018567 AllianceGenome:MGI:1861742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables microtubule binding activity. Acts upstream of or within microtubule cytoskeleton organization. Located in several cellular components, including cytoskeleton; smooth endoplasmic reticulum; and sperm midpiece. Part of microtubule associated complex. Is expressed in retina inner plexiform layer and spinal cord. Orthologous to human GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 222.5), testis adult (RPKM 209.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 B3; 11 42.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69882196..69885775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69991370..69994949)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene claudin 7 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69793405-69793588 Neighboring gene STARR-positive B cell enhancer ABC_E3967 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69804503-69804686 Neighboring gene STARR-positive B cell enhancer ABC_E2997 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69808904-69809245 Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
gamma-aminobutyric acid receptor-associated protein
Names
GABA-A receptor-associated protein
gamma-aminobutyric acid reseptor associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019749.4NP_062723.1  gamma-aminobutyric acid receptor-associated protein

    See identical proteins and their annotated locations for NP_062723.1

    Status: VALIDATED

    Source sequence(s)
    AL596185, AV029091
    Consensus CDS
    CCDS24928.1
    UniProtKB/Swiss-Prot
    B1AR49, Q9DCD6, Q9QUI7
    Related
    ENSMUSP00000018711.9, ENSMUST00000018711.15
    Conserved Domains (1) summary
    cd17232
    Location:2116
    Ubl_ATG8_GABARAP; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69882196..69885775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)