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Tbk1 TANK-binding kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 56480, updated on 27-Feb-2024

Summary

Official Symbol
Tbk1provided by MGI
Official Full Name
TANK-binding kinase 1provided by MGI
Primary source
MGI:MGI:1929658
See related
Ensembl:ENSMUSG00000020115 AllianceGenome:MGI:1929658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200008B05Rik
Summary
Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.5), CNS E11.5 (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Tbk1 in Genome Data Viewer
Location:
10 D2; 10 69.84 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121382360..121422699, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121546455..121586794, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6933 Neighboring gene predicted gene, 46204 Neighboring gene predicted gene, 35696 Neighboring gene STARR-positive B cell enhancer ABC_E1129 Neighboring gene STARR-positive B cell enhancer ABC_E9355 Neighboring gene STARR-seq mESC enhancer starr_28102 Neighboring gene exportin, tRNA (nuclear export receptor for tRNAs) Neighboring gene predicted gene, 35816 Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene STARR-seq mESC enhancer starr_28105

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC150301, MGC150302

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendritic cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cellular metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase TBK1
Names
T2K
NP_062760.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019786.4NP_062760.3  serine/threonine-protein kinase TBK1

    See identical proteins and their annotated locations for NP_062760.3

    Status: VALIDATED

    Source sequence(s)
    AC124413, AK004649, BC129910, BU708441, BU758191
    Consensus CDS
    CCDS24212.1
    UniProtKB/Swiss-Prot
    Q9CT90, Q9DC03, Q9WUN2
    UniProtKB/TrEMBL
    A1L361, Q3THP3
    Related
    ENSMUSP00000020316.3, ENSMUST00000020316.4
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121382360..121422699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)