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EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Homo sapiens (human) ]

Gene ID: 56478, updated on 7-Jun-2020

Summary

Official Symbol
EIF4ENIF1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E nuclear import factor 1provided by HGNC
Primary source
HGNC:HGNC:16687
See related
Ensembl:ENSG00000184708 MIM:607445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4E-T; Clast4
Summary
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See EIF4ENIF1 in Genome Data Viewer
Location:
22q12.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31434648..31489950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31835345..31885936, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 338, pseudogene Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene RNA, U6 small nuclear 28, pseudogene Neighboring gene SFI1 centrin binding protein Neighboring gene H2A.Z histone pseudogene 6 Neighboring gene ribosomal protein S18 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21601, FLJ26551

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear export IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IEA
Inferred from Electronic Annotation
more info
 
PML body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E transporter
Names
2610509L04Rik
4E-transporter
eIF4E transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164501.2NP_001157973.1  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_001157973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK314636, BC032941, BC033028, DA336484
    Consensus CDS
    CCDS13898.1
    UniProtKB/Swiss-Prot
    Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Related
    ENSP00000380659.1, ENST00000397525.5
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  2. NM_001164502.2NP_001157974.1  eukaryotic translation initiation factor 4E transporter isoform b

    See identical proteins and their annotated locations for NP_001157974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK314636, BC032941
    Consensus CDS
    CCDS54520.1
    UniProtKB/Swiss-Prot
    Q9NRA8
    Related
    ENSP00000342927.5, ENST00000344710.9
    Conserved Domains (1) summary
    pfam10477
    Location:85537
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  3. NM_019843.4NP_062817.2  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_062817.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK314636, BC032941
    Consensus CDS
    CCDS13898.1
    UniProtKB/Swiss-Prot
    Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Related
    ENSP00000328103.5, ENST00000330125.10
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    31434648..31489950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530280.2XP_011528582.1  eukaryotic translation initiation factor 4E transporter isoform X4

    See identical proteins and their annotated locations for XP_011528582.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  2. XM_005261688.3XP_005261745.1  eukaryotic translation initiation factor 4E transporter isoform X3

    See identical proteins and their annotated locations for XP_005261745.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  3. XM_005261686.3XP_005261743.1  eukaryotic translation initiation factor 4E transporter isoform X3

    See identical proteins and their annotated locations for XP_005261743.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  4. XM_017028863.2XP_016884352.1  eukaryotic translation initiation factor 4E transporter isoform X2

  5. XM_006724281.4XP_006724344.3  eukaryotic translation initiation factor 4E transporter isoform X1

  6. XM_005261687.3XP_005261744.1  eukaryotic translation initiation factor 4E transporter isoform X3

    See identical proteins and their annotated locations for XP_005261744.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  7. XM_017028864.2XP_016884353.1  eukaryotic translation initiation factor 4E transporter isoform X4

    UniProtKB/Swiss-Prot
    Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  8. XM_011530281.3XP_011528583.1  eukaryotic translation initiation factor 4E transporter isoform X3

    See identical proteins and their annotated locations for XP_011528583.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RNA

  1. XR_001755264.2 RNA Sequence

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