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EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Homo sapiens (human) ]

Gene ID: 56478, updated on 23-Oct-2022

Summary

Official Symbol
EIF4ENIF1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E nuclear import factor 1provided by HGNC
Primary source
HGNC:HGNC:16687
See related
Ensembl:ENSG00000184708 MIM:607445; AllianceGenome:HGNC:16687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4E-T; Clast4
Summary
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See EIF4ENIF1 in Genome Data Viewer
Location:
22q12.2
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31436963..31493568, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31903969..31954469, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31835353..31885828, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 338, pseudogene Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene RNA, U6 small nuclear 28, pseudogene Neighboring gene SFI1 centrin binding protein Neighboring gene H2A.Z histone pseudogene 6 Neighboring gene ribosomal protein S18 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21601, FLJ26551

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in P-body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear export IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E transporter
Names
2610509L04Rik
4E-transporter
eIF4E transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164501.2NP_001157973.1  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_001157973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK314636, BC032941, BC033028, DA336484
    Consensus CDS
    CCDS13898.1
    UniProtKB/Swiss-Prot
    Q9H708, Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Related
    ENSP00000380659.1, ENST00000397525.5
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  2. NM_001164502.2NP_001157974.1  eukaryotic translation initiation factor 4E transporter isoform b

    See identical proteins and their annotated locations for NP_001157974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK314636, BC032941
    Consensus CDS
    CCDS54520.1
    UniProtKB/Swiss-Prot
    Q9NRA8
    Related
    ENSP00000342927.5, ENST00000344710.9
    Conserved Domains (1) summary
    pfam10477
    Location:85537
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  3. NM_019843.4NP_062817.2  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_062817.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK314636, BC032941
    Consensus CDS
    CCDS13898.1
    UniProtKB/Swiss-Prot
    Q9H708, Q9NRA8
    UniProtKB/TrEMBL
    A0A024R1K0
    Related
    ENSP00000328103.5, ENST00000330125.10
    Conserved Domains (1) summary
    pfam10477
    Location:30711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31436963..31493568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530280.3XP_011528582.2  eukaryotic translation initiation factor 4E transporter isoform X3

  2. XM_005261688.4XP_005261745.2  eukaryotic translation initiation factor 4E transporter isoform X2

  3. XM_005261686.4XP_005261743.1  eukaryotic translation initiation factor 4E transporter isoform X4

    See identical proteins and their annotated locations for XP_005261743.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  4. XM_005261687.4XP_005261744.1  eukaryotic translation initiation factor 4E transporter isoform X4

    See identical proteins and their annotated locations for XP_005261744.1

    UniProtKB/Swiss-Prot
    Q9NRA8
    Conserved Domains (1) summary
    pfam10477
    Location:30712
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
  5. XM_006724281.5XP_006724344.3  eukaryotic translation initiation factor 4E transporter isoform X1

RNA

  1. XR_007067979.1 RNA Sequence

  2. XR_007067978.1 RNA Sequence

  3. XR_007067977.1 RNA Sequence

  4. XR_001755264.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31903969..31954469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)