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zmynd8 zinc finger, MYND-type containing 8 [ Danio rerio (zebrafish) ]

Gene ID: 564460, updated on 8-Mar-2025

Summary

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Official Symbol
zmynd8provided by ZNC
Official Full Name
zinc finger, MYND-type containing 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-041119-1
See related
Ensembl:ENSDARG00000007601 AllianceGenome:ZFIN:ZDB-GENE-041119-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkcbp1
Summary
Predicted to enable transcription corepressor activity. Predicted to act upstream of or within phosphorylation and regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Orthologous to human ZMYND8 (zinc finger MYND-type containing 8). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See zmynd8 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18560996..18604456, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18398656..18442176, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 5a Neighboring gene death inducer-obliterator 1 Neighboring gene nuclear receptor coactivator 3 Neighboring gene inhibitor of DNA binding 1, HLH protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. Kuroyanagi J, et al. FEBS Lett, 2014 Sep 17. PMID 25117453
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein kinase C-binding protein 1; MYND-type zinc finger-containing chromatin reader ZMYND8
Names
protein kinase C binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    18560996..18604456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479798.2 → XP_021335473.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q7N0
    Conserved Domains (8) summary
    cd05841
    Location:264 → 344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146 → 244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85 → 125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:1080 → 1114
    zf-MYND; MYND finger
    pfam07798
    Location:985 → 1076
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:415 → 614
    DUF3544; Domain of unknown function (DUF3544)
    cl26267
    Location:11 → 128
    ING; Inhibitor of growth proteins N-terminal histone-binding
    cl26464
    Location:638 → 810
    Atrophin-1; Atrophin-1 family

  2. XM_687794.10 → XP_692886.6  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform X2

    UniProtKB/TrEMBL
    A0A0R4ISB9, A0A8N7T7N3
    Related
    ENSDARP00000137232.1, ENSDART00000171183.2
    Conserved Domains (7) summary
    cd05841
    Location:290 → 370
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:172 → 270
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    COG5034
    Location:11 → 154
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15538
    Location:111 → 151
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:1106 → 1140
    zf-MYND; MYND finger
    pfam07798
    Location:1011 → 1102
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:449 → 639
    DUF3544; Domain of unknown function (DUF3544)

  3. XM_068224316.1 → XP_068080417.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform X4

    UniProtKB/TrEMBL
    A0AB32U3P1

  4. XM_068224315.1 → XP_068080416.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform X1

    UniProtKB/TrEMBL
    A0AB32U2N5
    Related
    ENSDARP00000155070.1, ENSDART00000182081.1

  5. XM_021479797.2 → XP_021335472.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Q412, A0A8M9PVE1
    Related
    ENSDARP00000145604.1, ENSDART00000180565.1
    Conserved Domains (8) summary
    cd05841
    Location:271 → 351
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:153 → 251
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:92 → 132
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:1087 → 1121
    zf-MYND; MYND finger
    pfam07798
    Location:992 → 1083
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:422 → 621
    DUF3544; Domain of unknown function (DUF3544)
    cl26267
    Location:6 → 135
    ING; Inhibitor of growth proteins N-terminal histone-binding
    cl26464
    Location:645 → 817
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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