lepb leptin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lepbprovided by ZNC
Official Full Name: leptin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-183
See related: AllianceGenome:ZFIN:ZDB-GENE-041210-183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-21o22.1
Summary: Predicted to enable hormone activity. Acts upstream of or within glucose homeostasis; regulation of primary metabolic process; and response to starvation. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; hypophysis; and pleuroperitoneal region. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (19031768..19033832, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (19042901..19044856, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts.
Title: leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts.
Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging.
Title: Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging.
Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish.
Title: Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish.
CRISPR mutagenesis of lepb did not increase beta-cell number.
Title: Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leptin b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.