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Stub1 STIP1 homology and U-Box containing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56424, updated on 9-May-2024

Summary

Official Symbol
Stub1provided by MGI
Official Full Name
STIP1 homology and U-Box containing protein 1provided by MGI
Primary source
MGI:MGI:1891731
See related
Ensembl:ENSMUSG00000039615 AllianceGenome:MGI:1891731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chip; 0610033N24Rik; 2210017D18Rik; 2310040B03Rik
Summary
Enables protein homodimerization activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Involved in several processes, including cellular response to topologically incorrect protein; positive regulation of ubiquitin-protein transferase activity; and proteolysis involved in cellular protein catabolic process. Acts upstream of or within protein polyubiquitination. Located in Z disc. Used to study autosomal recessive spinocerebellar ataxia 16. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 98.0), limb E14.5 (RPKM 89.5) and 28 other tissues See more
Orthologs
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Genomic context

See Stub1 in Genome Data Viewer
Location:
17 A3.3; 17 12.93 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26049608..26051893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25830634..25832919, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E3192 Neighboring gene microRNA 3082 Neighboring gene rhomboid like 1 Neighboring gene ras homolog family member T2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables Hsp70 protein binding TAS
Traceable Author Statement
more info
PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables TPR domain binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding TAS
Traceable Author Statement
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in protein maturation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of glucocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucocorticoid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin conjugating enzyme complex TAS
Traceable Author Statement
more info
PubMed 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CHIP
Names
RING-type E3 ubiquitin transferase CHIP
carboxy terminus of Hsp70-interacting protein
NP_062693.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019719.4NP_062693.1  E3 ubiquitin-protein ligase CHIP

    See identical proteins and their annotated locations for NP_062693.1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS28533.1
    UniProtKB/Swiss-Prot
    Q9DCJ0, Q9WUD1
    UniProtKB/TrEMBL
    Q3TYJ0
    Related
    ENSMUSP00000040431.9, ENSMUST00000044911.10
    Conserved Domains (3) summary
    sd00006
    Location:2755
    TPR; TPR repeat [structural motif]
    cd16654
    Location:228294
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    cl26005
    Location:27127
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RNA

  1. NR_157361.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Related
    ENSMUST00000236361.2
  2. NR_157362.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Related
    ENSMUST00000236565.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26049608..26051893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)