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LTB4R2 leukotriene B4 receptor 2 [ Homo sapiens (human) ]

Gene ID: 56413, updated on 4-Jun-2020

Summary

Official Symbol
LTB4R2provided by HGNC
Official Full Name
leukotriene B4 receptor 2provided by HGNC
Primary source
HGNC:HGNC:19260
See related
Ensembl:ENSG00000213906 MIM:605773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLT2; NOP9; BLTR2; JULF2; KPG_004; LTB4-R2; LTB4-R 2
Expression
Broad expression in skin (RPKM 12.7), spleen (RPKM 9.3) and 21 other tissues See more
Orthologs

Genomic context

See LTB4R2 in Genome Data Viewer
Location:
14q12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24310140..24312053)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24779357..24781259)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102725044 Neighboring gene dehydrogenase/reductase 1 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene NOP9 nucleolar protein Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4 Neighboring gene receptor interacting serine/threonine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene B4 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukotriene B4 receptor 2
Names
LTB4 receptor JULF2
leukotriene B4 receptor BLT2
seven transmembrane receptor BLTR2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164692.2NP_001158164.1  leukotriene B4 receptor 2

    See identical proteins and their annotated locations for NP_001158164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK304169, BC038437, DC408599
    Consensus CDS
    CCDS9625.2
    UniProtKB/Swiss-Prot
    Q9NPC1
    UniProtKB/TrEMBL
    B4E292
    Related
    ENSP00000445772.1, ENST00000543919.1
    Conserved Domains (2) summary
    cd14964
    Location:2347
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_019839.5NP_062813.2  leukotriene B4 receptor 2

    See identical proteins and their annotated locations for NP_062813.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB032558, AK304169, AL096870, DC408599
    Consensus CDS
    CCDS9625.2
    UniProtKB/Swiss-Prot
    Q9NPC1
    UniProtKB/TrEMBL
    B4E292
    Related
    ENSP00000433290.1, ENST00000533293.2
    Conserved Domains (2) summary
    cd14964
    Location:2347
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24310140..24312053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    611118..613031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001164693.1: Suppressed sequence

    Description
    NM_001164693.1: This RefSeq was permanently suppressed because there is not sufficient data to support splicing of an intron with non-consensus splice sites in the CDS.
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