trmt5 tRNA methyltransferase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trmt5provided by ZNC
Official Full Name: tRNA methyltransferase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5978
See related: Ensembl:ENSDARG00000069278 AllianceGenome:ZFIN:ZDB-GENE-030131-5978
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi28b08
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to act upstream of or within tRNA methylation. Predicted to be located in mitochondrion and nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (35089464..35095440, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (31681988..31687925, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fi28b08.x1 (e-PCR)
- UniSTS:197175

AW154524 (e-PCR)
- UniSTS:205907

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA N1-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA (guanine(37)-N(1))-methyltransferase

Names: TRM5 tRNA methyltransferase 5 homolog; tRNA (guanine-N(1)-)-methyltransferase

NP_001139055.1

EC 2.1.1.228

XP_073775810.1

EC 2.1.1.228

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.