pigo phosphatidylinositol glycan anchor biosynthesis, class O [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pigoprovided by ZNC
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Oprovided by ZNC
Primary source: ZFIN:ZDB-GENE-091204-80
See related: Ensembl:ENSDARG00000011743 AllianceGenome:ZFIN:ZDB-GENE-091204-80
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-200l5.3
Summary: Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (17747851..17759878)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (17790409..17802444)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables mannose-ethanolamine phosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-ethanolamine phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_068223941.1 → XP_068080042.1 GPI ethanolamine phosphate transferase 3 isoform X2
XM_687353.9 → XP_692445.3 GPI ethanolamine phosphate transferase 3 isoform X1

UniProtKB/TrEMBL

A0A8N7TDE4, E9QI13

Related

ENSDARP00000118783.1, ENSDART00000135044.2

Conserved Domains (2) summary

COG1524
Location:59 → 278

Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]

cd16023
Location:59 → 334

GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O