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B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 56386, updated on 24-Sep-2025
Official Symbol
B4galt6provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6provided by MGI
Primary source
MGI:MGI:1928380
See related
Ensembl:ENSMUSG00000056124 AllianceGenome:MGI:1928380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide and neurogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in small intestine adult (RPKM 16.5), duodenum adult (RPKM 16.3) and 23 other tissues See more
Orthologs
human all
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See B4galt6 in Genome Data Viewer
Location:
18 A2; 18 11.48 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20817656..20879461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20684599..20746404, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16090 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene transthyretin Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene trafficking protein particle complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. Nomura T, et al. J Biol Chem, 1998 May 29. PMID 9593693
  2. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Yoshihara T, et al. PLoS Genet, 2018 Aug. PMID 30114188, Free PMC Article
  3. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Tokuda N, et al. Glycobiology, 2013 Oct. PMID 23882130
  4. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Mayo L, et al. Nat Med, 2014 Oct. PMID 25216636, Free PMC Article
  5. A hypomorphic lsd1 allele results in heart development defects in mice. Nicholson TB, et al. PLoS One, 2013. PMID 23637775, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ganglioside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactosylceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
beta-1,4-galactosyltransferase 6
Names
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
b4Gal-T6
beta-1, 4-galactosyltransferase VI
beta-1,4-GalTase 6
beta4Gal-T6
glucosylceramide beta-1,4-galactosyltransferase
lacCer synthase
lactosylceramide synthase
NP_062711.1
XP_030106406.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019737.2 → NP_062711.1  beta-1,4-galactosyltransferase 6

    See identical proteins and their annotated locations for NP_062711.1

    Status: VALIDATED

    Source sequence(s)
    AC129078, AF097158
    Consensus CDS
    CCDS29086.1
    UniProtKB/Swiss-Prot
    Q9WVK5
    UniProtKB/TrEMBL
    Q3UUA9, Q3UUN1
    Related
    ENSMUSP00000066515.6, ENSMUST00000070080.6
    Conserved Domains (1) summary
    cd00899
    Location:155 → 371
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    20817656..20879461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250546.2 → XP_030106406.1  beta-1,4-galactosyltransferase 6 isoform X1

    UniProtKB/TrEMBL
    Q3TPM8, Q3UUN1
    Conserved Domains (1) summary
    cd00899
    Location:111 → 327
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVK5.1 GenPept UniProtKB/Swiss-Prot:Q9WVK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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