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Letm1 leucine zipper-EF-hand containing transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56384, updated on 5-Jan-2023

Summary

Official Symbol
Letm1provided by MGI
Official Full Name
leucine zipper-EF-hand containing transmembrane protein 1provided by MGI
Primary source
MGI:MGI:1932557
See related
Ensembl:ENSMUSG00000005299 AllianceGenome:MGI:1932557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calcium:proton antiporter activity. Involved in cellular calcium ion homeostasis and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in gonad and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.7), colon adult (RPKM 16.5) and 28 other tissues See more
Orthologs
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Genomic context

See Letm1 in Genome Data Viewer
Location:
5; 5 B2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33897017..33940061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33739673..33782717, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 129 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene microRNA 7024 Neighboring gene negative elongation factor complex member A, Whsc2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial proton/calcium exchanger protein
Names
LETM1 and EF-hand domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019694.2NP_062668.1  mitochondrial proton/calcium exchanger protein precursor

    See identical proteins and their annotated locations for NP_062668.1

    Status: VALIDATED

    Source sequence(s)
    AF061026, AK163499, BQ178952, BY110340, BY243359
    Consensus CDS
    CCDS19207.1
    UniProtKB/Swiss-Prot
    Q8K5E5, Q9Z2I0
    Related
    ENSMUSP00000005431.6, ENSMUST00000005431.6
    Conserved Domains (1) summary
    pfam07766
    Location:154409
    LETM1; LETM1-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33897017..33940061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504034.5XP_006504097.1  mitochondrial proton/calcium exchanger protein isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:2237
    LETM1; LETM1-like protein