map3k8 mitogen-activated protein kinase kinase kinase 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map3k8provided by ZNC
Official Full Name: mitogen-activated protein kinase kinase kinase 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-100316-8
See related: Ensembl:ENSDARG00000061710 AllianceGenome:ZFIN:ZDB-GENE-100316-8
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	12	NC_133187.1 (25353503..25365667, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (23645755..23658915, complement)

Chromosome 12 - NC_133187.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info