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foxo4 forkhead box O4 [ Danio rerio (zebrafish) ]

Gene ID: 563719, updated on 4-Jan-2025

Summary

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Official Symbol
foxo4provided by ZNC
Official Full Name
forkhead box O4provided by ZNC
Primary source
ZFIN:ZDB-GENE-150311-1
See related
Ensembl:ENSDARG00000055792 AllianceGenome:ZFIN:ZDB-GENE-150311-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within intracellular oxygen homeostasis and response to hypoxia. Predicted to be active in nucleus. Is expressed in blastoderm; brain; eye; muscle; and pericardial region. Orthologous to human FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See foxo4 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (30908603..30917926)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (30568227..30577612)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like 3b Neighboring gene solute carrier family 7 member 3b Neighboring gene si:ch211-126c2.4 Neighboring gene sestrin 4 Neighboring gene si:ch211-191o15.6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. Shi L, et al. Int J Mol Sci, 2023 May 18. PMID 37240290, Free PMC Article
  2. Modulation of redox and insulin signaling underlie the anti-hyperglycemic and antioxidant effects of diphenyl diselenide in zebrafish. Dos Santos MM, et al. Free Radic Biol Med, 2020 Oct. PMID 32544425
  3. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Wang Y, et al. Genome Biol Evol, 2015 Oct 9. PMID 26454018, Free PMC Article
  4. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. Shimizu H, et al. Elife, 2017 Aug 19. PMID 28826496, Free PMC Article
  5. Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Lin SJ, et al. Dev Genes Evol, 2017 Jun. PMID 28154937

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that foxo4, foxo6a, and foxo6b play important roles in the developing brain and retina and that the transcriptional levels of these genes are regulated by PI3-kinase signaling.
    Title: Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular oxygen homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
forkhead box protein O4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    30908603..30917926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291168.4 → XP_009289443.1  forkhead box protein O4

    UniProtKB/TrEMBL
    A0A8M3APA3, F1R3E6
    Related
    ENSDARP00000072649.4, ENSDART00000078187.6
    Conserved Domains (3) summary
    cd00059
    Location:94 → 174
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:375 → 450
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:564 → 602
    FOXO-TAD; Transactivation domain of FOXO protein family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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