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Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 [ Mus musculus (house mouse) ]

Gene ID: 56363, updated on 26-Sep-2022

Summary

Official Symbol
Tmeff2provided by MGI
Official Full Name
transmembrane protein with EGF-like and two follistatin-like domains 2provided by MGI
Primary source
MGI:MGI:1861735
See related
Ensembl:ENSMUSG00000026109 AllianceGenome:MGI:1861735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR-2; 4832418D20Rik; 7630402F16Rik
Summary
Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basement membrane and plasma membrane. Is expressed in several structures, including embryo mesenchyme; intestine; and nervous system. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 14.7), CNS E18 (RPKM 13.1) and 13 other tissues See more
Orthologs
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Genomic context

See Tmeff2 in Genome Data Viewer
Location:
1; 1 C1.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (50951946..51226429)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (50900683..51187270)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene predicted gene 28321 Neighboring gene RIKEN cDNA 9330175M20 gene Neighboring gene caveolae associated 2 Neighboring gene THO complex 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019790.4NP_062764.1  tomoregulin-2 precursor

    See identical proteins and their annotated locations for NP_062764.1

    Status: VALIDATED

    Source sequence(s)
    AK029307
    Consensus CDS
    CCDS14939.1
    UniProtKB/Swiss-Prot
    Q9JJE3, Q9QYM9
    UniProtKB/TrEMBL
    A0A6P5P943
    Related
    ENSMUSP00000080533.4, ENSMUST00000081851.4
    Conserved Domains (3) summary
    PHA02887
    Location:236301
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:181227
    KAZAL; Kazal type serine protease inhibitors
    cd00104
    Location:95135
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    50951946..51226429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255650.2XP_030111510.1  tomoregulin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJE3
    UniProtKB/TrEMBL
    A0A6P5P943
    Conserved Domains (3) summary
    PHA02887
    Location:236301
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:181227
    KAZAL; Kazal type serine protease inhibitors
    cd00104
    Location:95135
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
  2. XM_036152485.1XP_036008378.1  tomoregulin-2 isoform X2

    Conserved Domains (3) summary
    PHA02887
    Location:245281
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:181227
    KAZAL; Kazal type serine protease inhibitors
    cd00104
    Location:95135
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...