ikbkb inhibitor of nuclear factor kappa B kinase subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ikbkbprovided by ZNC
Official Full Name: inhibitor of nuclear factor kappa B kinase subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-071115-2
See related: Ensembl:ENSDARG00000079123 AllianceGenome:ZFIN:ZDB-GENE-071115-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ikk2
Summary: Enables kinase activity. Acts upstream of or within regulation of cytokinesis and skin development. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	8	NC_133183.1 (3548521..3640067)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (2319091..2406699)

Chromosome 8 - NC_133183.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z6763 (e-PCR), detects polymorphism
- UniSTS:204916

G40464 (e-PCR)
- UniSTS:61816

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IkappaB kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: Ikkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

NP_001116737.1

EC 2.7.11.10

XP_073765759.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123265.1 → NP_001116737.1 inhibitor of nuclear factor kappa-B kinase subunit beta

Status: PROVISIONAL

Source sequence(s)

JBMGRA010000008

UniProtKB/TrEMBL

A0A8M1NIE6, B0R199

Related

ENSDARP00000117685.1, ENSDART00000140265.2

Conserved Domains (2) summary

cd14038
Location:20 → 338

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

cl25424
Location:329 → 380

TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...