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pde3b phosphodiesterase 3B [ Danio rerio (zebrafish) ]

Gene ID: 563432, updated on 9-Sep-2025
Official Symbol
pde3bprovided by ZNC
Official Full Name
phosphodiesterase 3Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-160728-20
See related
Ensembl:ENSDARG00000062190 AllianceGenome:ZFIN:ZDB-GENE-160728-20
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-79e4.4
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Is expressed in oocyte and oocyte stage V. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 7 NC_133182.1 (27726289..27822484, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 7 NC_007118.7 (27702489..27798689, complement)

Chromosome 7 - NC_133182.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 6 Neighboring gene cytochrome P450, family 2, subfamily R, polypeptide 1 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha Neighboring gene uncharacterized LOC141375371 Neighboring gene uncharacterized LOC141375372 Neighboring gene COPI coat complex subunit beta 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Pang Y, et al. Gen Comp Endocrinol, 2018 Sep 1. PMID 29574150
  2. Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. Bu H, et al. JCI Insight, 2021 Dec 22. PMID 34935644, Free PMC Article
  3. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cAMP/PKA signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Names
phosphodiesterase 3B, cGMP-inhibited
XP_073764622.1
XP_073764623.1
XP_073764624.1
XP_691883.5

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133182.1 Reference GRCz12tu Primary Assembly

    Range
    27726289..27822484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686791.11 → XP_691883.5  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1

    UniProtKB/TrEMBL
    A0A1D5NSM7, A0A8N7TEY5

  2. XM_073908523.1 → XP_073764624.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2

  3. XM_073908522.1 → XP_073764623.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2

  4. XM_073908521.1 → XP_073764622.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2

RNA

  1. XR_012383311.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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