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PPAN peter pan homolog [ Homo sapiens (human) ]

Gene ID: 56342, updated on 12-Oct-2019

Summary

Official Symbol
PPANprovided by HGNC
Official Full Name
peter pan homologprovided by HGNC
Primary source
HGNC:HGNC:9227
See related
Ensembl:ENSG00000130810 MIM:607793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSF; SSF1; SSF2; BXDC3; SSF-1
Summary
The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in appendix (RPKM 9.7), spleen (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See PPAN in Genome Data Viewer
Location:
19p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10106223..10112012)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10216899..10221975)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene complement component 3 precursor pseudogene Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting Neighboring gene angiopoietin like 6 Neighboring gene PPAN-P2RY11 readthrough Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene purinergic receptor P2Y11 Neighboring gene eukaryotic translation initiation factor 3 subunit G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, peter pan homolog (PPAN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PPAN is increased by RRE PubMed
nucleocapsid gag HIV-1 NC downregulates peter pan homolog (Drosophila) in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough PPAN-P2RY11

Readthrough gene: PPAN-P2RY11, Included gene: P2RY11

Homology

Clone Names

  • MGC14226, MGC45852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
suppressor of SWI4 1 homolog
Names
brix domain-containing protein 3
homolog of S. cerevisiae SSF1
second-step splicing factor 1
suppressor of sterile four 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051640.1 RefSeqGene

    Range
    5140..10790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346139.1NP_001333068.1  suppressor of SWI4 1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC020931
  2. NM_001346141.1NP_001333070.1  suppressor of SWI4 1 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC020931
    Consensus CDS
    CCDS86698.1
    UniProtKB/TrEMBL
    A8MV53
    Related
    ENSP00000377382.1, ENST00000393793.5
  3. NM_020230.7NP_064615.3  suppressor of SWI4 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_064615.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC020931, BC033202
    Consensus CDS
    CCDS12225.1
    UniProtKB/Swiss-Prot
    Q9NQ55
    Related
    ENSP00000253107.7, ENST00000253107.12
    Conserved Domains (2) summary
    smart00879
    Location:32201
    Brix; The Brix domain is found in a number of eukaryotic proteins
    cl00935
    Location:270341
    Brix; Brix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10106223..10112012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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