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PRMT8 protein arginine methyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 56341, updated on 5-Apr-2020

Summary

Official Symbol
PRMT8provided by HGNC
Official Full Name
protein arginine methyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:5188
See related
Ensembl:ENSG00000111218 MIM:610086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRMT1L3; HRMT1L4
Summary
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue See more
Orthologs

Genomic context

See PRMT8 in Genome Data Viewer
Location:
12p13.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (3381349..3593973)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (3490515..3703139)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128253 Neighboring gene long intergenic non-protein coding RNA 2827 Neighboring gene tetraspanin 11 pseudogene Neighboring gene long intergenic non-protein coding RNA 2417 Neighboring gene uncharacterized LOC105369607 Neighboring gene ribosomal protein S26 pseudogene 44 Neighboring gene thyroid cancer-associated transcript 155 Neighboring gene calcium release activated channel regulator 2A Neighboring gene RNA, U6 small nuclear 174, pseudogene Neighboring gene uncharacterized LOC107984495

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone arginine methylation IEA
Inferred from Electronic Annotation
more info
 
histone methylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-arginine methylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
protein methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of the cytoplasmic side of the plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein arginine N-methyltransferase 8
Names
HMT1 hnRNP methyltransferase-like 3
arginine methyltransferase 8
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
protein arginine N-methyltransferase 4
NP_001243465.1
NP_062828.3
XP_016875133.1
XP_016875134.1
XP_024304827.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256536.1NP_001243465.1  protein arginine N-methyltransferase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC005831, AK315619
    Consensus CDS
    CCDS58200.1
    UniProtKB/Swiss-Prot
    Q9NR22
    Related
    ENSP00000414507.2, ENST00000452611.6
    Conserved Domains (1) summary
    cd02440
    Location:106206
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_019854.5NP_062828.3  protein arginine N-methyltransferase 8 isoform 1

    See identical proteins and their annotated locations for NP_062828.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209027, BC022458, DA200375
    Consensus CDS
    CCDS8521.2
    UniProtKB/Swiss-Prot
    Q9NR22
    UniProtKB/TrEMBL
    Q59GT2
    Related
    ENSP00000372067.3, ENST00000382622.4
    Conserved Domains (1) summary
    cd02440
    Location:115215
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    3381349..3593973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019644.1XP_016875133.1  protein arginine N-methyltransferase 8 isoform X1

  2. XM_024449059.1XP_024304827.1  protein arginine N-methyltransferase 8 isoform X3

    Conserved Domains (2) summary
    cd02440
    Location:115215
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:61278
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
  3. XM_017019645.1XP_016875134.1  protein arginine N-methyltransferase 8 isoform X2

RNA

  1. XR_001748813.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256537.1: Suppressed sequence

    Description
    NM_001256537.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which may retain intronic sequence at its 5' end.
  2. NR_046301.1: Suppressed sequence

    Description
    NR_046301.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which may be incomplete at its 5' end.
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