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PRPS2 phosphoribosyl pyrophosphate synthetase 2 [ Homo sapiens (human) ]

Gene ID: 5634, updated on 5-Apr-2020

Summary

Official Symbol
PRPS2provided by HGNC
Official Full Name
phosphoribosyl pyrophosphate synthetase 2provided by HGNC
Primary source
HGNC:HGNC:9465
See related
Ensembl:ENSG00000101911 MIM:311860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRSII
Summary
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Broad expression in testis (RPKM 94.5), adrenal (RPKM 26.5) and 22 other tissues See more
Orthologs

Genomic context

See PRPS2 in Genome Data Viewer
Location:
Xp22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (12791355..12824227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12809474..12842346)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene ribosomal protein L17 pseudogene 49 Neighboring gene RN7SK pseudogene 290 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 4 Neighboring gene proteasome subunit alpha 6 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribose-phosphate pyrophosphokinase 2
Names
PPRibP synthetase
PRS-II
phosphoribosyl pyrophosphate synthase II
ribose-phosphate diphosphokinase 2
testicular secretory protein Li 41
NP_001034180.1
NP_002756.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016717.1 RefSeqGene

    Range
    5001..37873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039091.2NP_001034180.1  ribose-phosphate pyrophosphokinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001034180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC110875, BC119662, BU675363, DA478574
    Consensus CDS
    CCDS43918.1
    UniProtKB/Swiss-Prot
    P11908
    UniProtKB/TrEMBL
    A0A140VK41
    Related
    ENSP00000381504.2, ENST00000398491.6
    Conserved Domains (1) summary
    COG0462
    Location:1316
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
  2. NM_002765.5NP_002756.1  ribose-phosphate pyrophosphokinase 2 isoform 2

    See identical proteins and their annotated locations for NP_002756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC110875, BU675363, DA478574
    Consensus CDS
    CCDS14150.1
    UniProtKB/Swiss-Prot
    P11908
    Related
    ENSP00000370043.5, ENST00000380668.9
    Conserved Domains (1) summary
    COG0462
    Location:1313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    12791355..12824227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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