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Abcb9 ATP-binding cassette, sub-family B member 9 [ Mus musculus (house mouse) ]

Gene ID: 56325, updated on 8-Feb-2024

Summary

Official Symbol
Abcb9provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 9provided by MGI
Primary source
MGI:MGI:1861729
See related
Ensembl:ENSMUSG00000029408 AllianceGenome:MGI:1861729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAPL; mKIAA1520
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thymus adult (RPKM 11.0), genital fat pad adult (RPKM 8.2) and 24 other tissues See more
Orthologs
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Genomic context

See Abcb9 in Genome Data Viewer
Location:
5 F; 5 63.36 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124199920..124234009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124061857..124095955, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 related Neighboring gene microRNA 7032 Neighboring gene vacuolar protein sorting 37B Neighboring gene STARR-positive B cell enhancer ABC_E10351 Neighboring gene predicted gene, 34086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124525186-124525369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124529132-124529326 Neighboring gene STARR-positive B cell enhancer ABC_E432 Neighboring gene predicted gene 16001 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type oligopeptide transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type peptide transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in peptide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ABC-type oligopeptide transporter ABCB9
Names
ABC transporter 9 protein
ATP-binding cassette transporter 9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
TAP-like protein
mABCB9
NP_063928.2
XP_017176501.1
XP_036021222.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019875.2NP_063928.2  ABC-type oligopeptide transporter ABCB9

    See identical proteins and their annotated locations for NP_063928.2

    Status: VALIDATED

    Source sequence(s)
    AC113474, AK044140
    Consensus CDS
    CCDS19671.1
    UniProtKB/Swiss-Prot
    Q8CHA1, Q9D212, Q9JIN1, Q9JJ59
    Related
    ENSMUSP00000031354.5, ENSMUST00000031354.11
    Conserved Domains (3) summary
    cd03248
    Location:489714
    ABCC_TAP; ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C
    TIGR00958
    Location:44734
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:189451
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124199920..124234009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165329.1XP_036021222.1  ABC-type oligopeptide transporter ABCB9 isoform X2

    Conserved Domains (1) summary
    TIGR00958
    Location:2444
    3a01208; Conjugate Transporter-2 (CT2) Family protein
  2. XM_017321012.1XP_017176501.1  ABC-type oligopeptide transporter ABCB9 isoform X1

    Conserved Domains (1) summary
    TIGR00958
    Location:2517
    3a01208; Conjugate Transporter-2 (CT2) Family protein

RNA

  1. XR_001784728.3 RNA Sequence