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chaf1a chromatin assembly factor 1, subunit A (p150) [ Danio rerio (zebrafish) ]

Gene ID: 563212, updated on 9-Sep-2025
Official Symbol
chaf1aprovided by ZNC
Official Full Name
chromatin assembly factor 1, subunit A (p150)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5366
See related
Ensembl:ENSDARG00000062152 AllianceGenome:ZFIN:ZDB-GENE-030131-5366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
caip150; CAF-Ip150; wu:fd14g10; zgc:153930
Summary
Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Is expressed in several structures, including eye; neural crest; neural tube; neuroepithelial cell; and ventricular zone. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See chaf1a in Genome Data Viewer
Location:
chromosome: 22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (22125320..22150098, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (22276749..22301922, complement)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene UBX domain protein 6 Neighboring gene si:ch211-129c21.1 Neighboring gene secretory carrier membrane protein 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Tao L, et al. Adv Sci (Weinh), 2021 Oct. PMID 34365742, Free PMC Article
  2. Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Wang YW, et al. Gene, 2013 May 25. PMID 23537994
  3. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
  4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAF-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
chromatin assembly factor 1 subunit A
Names
CAF-1 subunit A
CAF-I 150 kDa subunit
CAF-I p150
Chromatin assembly factor I p150 subunit

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045013.3 → NP_001038478.3  chromatin assembly factor 1 subunit A

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000022
    Related
    ENSDARP00000101598.2, ENSDART00000111711.4

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    22125320..22150098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073936616.1 → XP_073792717.1  chromatin assembly factor 1 subunit A isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JMK9.1 GenPept UniProtKB/Swiss-Prot:A0JMK9

Gene LinkOut

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