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Ggcx gamma-glutamyl carboxylase [ Mus musculus (house mouse) ]

Gene ID: 56316, updated on 6-Jun-2024

Summary

Official Symbol
Ggcxprovided by MGI
Official Full Name
gamma-glutamyl carboxylaseprovided by MGI
Primary source
MGI:MGI:1927655
See related
Ensembl:ENSMUSG00000053460 AllianceGenome:MGI:1927655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable gamma-glutamyl carboxylase activity and vitamin binding activity. Predicted to be involved in peptidyl-glutamic acid carboxylation. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 17.5), lung adult (RPKM 13.1) and 27 other tissues See more
Orthologs
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Genomic context

See Ggcx in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72391262..72407696)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72414279..72433359)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 5 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E10385 Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene STARR-positive B cell enhancer ABC_E6440 Neighboring gene methionine adenosyltransferase 2A Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene STARR-seq mESC enhancer starr_16285 Neighboring gene STARR-seq mESC enhancer starr_16286 Neighboring gene STARR-seq mESC enhancer starr_16287 Neighboring gene SH2 domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-glutamyl carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gamma-glutamyl carboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables gamma-glutamyl carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables gamma-glutamyl carboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables gamma-glutamyl carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables vitamin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vitamin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in peptidyl-glutamic acid carboxylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-glutamic acid carboxylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vitamin K metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vitamin K-dependent gamma-carboxylase
Names
peptidyl-glutamate 4-carboxylase
vitamin K gamma glutamyl carboxylase
NP_001398233.1
NP_062776.1
XP_006506479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411304.1NP_001398233.1  vitamin K-dependent gamma-carboxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116115
    UniProtKB/TrEMBL
    Q3TME3
  2. NM_019802.6NP_062776.1  vitamin K-dependent gamma-carboxylase isoform 1

    See identical proteins and their annotated locations for NP_062776.1

    Status: VALIDATED

    Source sequence(s)
    AC116115
    Consensus CDS
    CCDS20242.1
    UniProtKB/Swiss-Prot
    Q3UXN5, Q8CCB3, Q9QYC7
    UniProtKB/TrEMBL
    B2RS80, Q3TME3
    Related
    ENSMUSP00000070109.8, ENSMUST00000065906.9
    Conserved Domains (2) summary
    smart00752
    Location:56315
    HTTM; Horizontally Transferred TransMembrane Domain
    pfam05090
    Location:66502
    VKG_Carbox; Vitamin K-dependent gamma-carboxylase

RNA

  1. NR_177208.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  2. NR_177209.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  3. NR_177210.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  4. NR_177211.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  5. NR_177212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  6. NR_177213.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
  7. NR_177214.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72391262..72407696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506416.5XP_006506479.1  vitamin K-dependent gamma-carboxylase isoform X2

    See identical proteins and their annotated locations for XP_006506479.1

    Conserved Domains (2) summary
    pfam05090
    Location:8276
    VKG_Carbox; Vitamin K-dependent gamma-carboxylase
    cl40423
    Location:284376
    cupin_RmlC-like; RmlC-like cupin superfamily

RNA

  1. XR_004933611.1 RNA Sequence