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Rhcg Rhesus blood group-associated C glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 56315, updated on 27-Feb-2024

Summary

Official Symbol
Rhcgprovided by MGI
Official Full Name
Rhesus blood group-associated C glycoproteinprovided by MGI
Primary source
MGI:MGI:1888517
See related
Ensembl:ENSMUSG00000030549 AllianceGenome:MGI:1888517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ammonium transmembrane transporter activity. Involved in ammonium transmembrane transport and regulation of pH. Located in apical plasma membrane. Is expressed in medulla oblongata basal plate ventricular layer; renal calyx; and spinal cord ventricular layer. Orthologous to human RHCG (Rh family C glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 120.3), kidney adult (RPKM 68.3) and 1 other tissue See more
Orthologs
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Genomic context

See Rhcg in Genome Data Viewer
Location:
7 D2; 7 45.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79243111..79267405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79593363..79617657, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Mir9-3 host gene Neighboring gene microRNA 9b-3 Neighboring gene microRNA 9-3 Neighboring gene STARR-seq mESC enhancer starr_19284 Neighboring gene predicted gene, 31740 Neighboring gene STARR-positive B cell enhancer ABC_E10444 Neighboring gene cullin 4B pseudogene Neighboring gene STARR-seq mESC enhancer starr_19286 Neighboring gene STARR-positive B cell enhancer ABC_E551 Neighboring gene TOPBP1-interacting checkpoint and replication regulator Neighboring gene kinesin family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ammonium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ammonium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
enables carbon dioxide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ammonium homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ammonium transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ammonium transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ammonium transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular monoatomic ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transepithelial ammonium transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ammonium transporter Rh type C
Names
Rh type C glycoprotein
rh family type C glycoprotein
rhesus blood group family type C glycoprotein
rhesus-associated C glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019799.3NP_062773.2  ammonium transporter Rh type C

    See identical proteins and their annotated locations for NP_062773.2

    Status: VALIDATED

    Source sequence(s)
    AI648871, AK076757
    Consensus CDS
    CCDS21383.1
    UniProtKB/Swiss-Prot
    Q8BVS0, Q9QXP0
    UniProtKB/TrEMBL
    B2RPX8
    Related
    ENSMUSP00000032766.5, ENSMUST00000032766.5
    Conserved Domains (1) summary
    cl03012
    Location:61436
    Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79243111..79267405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250878.4XP_011249180.1  ammonium transporter Rh type C isoform X1

    UniProtKB/TrEMBL
    B2RPX8
    Conserved Domains (1) summary
    cl03012
    Location:39411
    Ammonium_transp; Ammonium Transporter Family
  2. XM_006541004.1XP_006541067.1  ammonium transporter Rh type C isoform X2

    Conserved Domains (1) summary
    cl03012
    Location:20287
    Ammonium_transp; Ammonium Transporter Family