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Nupr1 nuclear protein transcription regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 56312, updated on 23-Mar-2024

Summary

Official Symbol
Nupr1provided by MGI
Official Full Name
nuclear protein transcription regulator 1provided by MGI
Primary source
MGI:MGI:1891834
See related
Ensembl:ENSMUSG00000030717 AllianceGenome:MGI:1891834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p8; Com1; 2310032H04Rik
Summary
Enables acetyltransferase activator activity and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of type B pancreatic cell proliferation; and positive regulation of neuroinflammatory response. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of fibroblast proliferation; and skeletal muscle cell differentiation. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; jaw; orbito-sphenoid; pancreas; and sensory organ. Used to study Sertoli cell-only syndrome. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 66.4), ovary adult (RPKM 63.7) and 15 other tissues See more
Orthologs
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Genomic context

See Nupr1 in Genome Data Viewer
Location:
7 F3; 7 69.21 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126222418..126224642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126623246..126625470, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein B receptor Neighboring gene interleukin 27 Neighboring gene predicted gene, 39086 Neighboring gene predicted gene, 39087 Neighboring gene SAGA complex associated factor 29 Neighboring gene STARR-seq mESC enhancer starr_20153 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (6) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables acetyltransferase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein modification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear protein 1
Names
nuclear transcriptional regulator protein 1
protein p8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019738.1NP_062712.1  nuclear protein 1

    See identical proteins and their annotated locations for NP_062712.1

    Status: PROVISIONAL

    Source sequence(s)
    AF131196
    Consensus CDS
    CCDS40127.1
    UniProtKB/Swiss-Prot
    Q9D756, Q9WTK0
    Related
    ENSMUSP00000032961.4, ENSMUST00000032961.4
    Conserved Domains (1) summary
    pfam10195
    Location:2477
    Phospho_p8; DNA-binding nuclear phosphoprotein p8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126222418..126224642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)