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Gps2 G protein pathway suppressor 2 [ Mus musculus (house mouse) ]

Gene ID: 56310, updated on 5-Mar-2024

Summary

Official Symbol
Gps2provided by MGI
Official Full Name
G protein pathway suppressor 2provided by MGI
Primary source
MGI:MGI:1891751
See related
Ensembl:ENSMUSG00000023170 AllianceGenome:MGI:1891751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPS-2
Summary
Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Part of transcription repressor complex. Orthologous to human GPS2 (G protein pathway suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 94.4), liver E14.5 (RPKM 85.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 B3; 11 42.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69804805..69807882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69913980..69917056)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5243 Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9140

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to mitochondrial depolarisation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein pathway suppressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357906.2NP_001344835.1  G protein pathway suppressor 2

    Status: VALIDATED

    Source sequence(s)
    AL596185, AW046264, BC138880
    Consensus CDS
    CCDS24922.1
    UniProtKB/Swiss-Prot
    Q921N8
    UniProtKB/TrEMBL
    Q9WV81
    Related
    ENSMUSP00000112062.2, ENSMUST00000116358.8
    Conserved Domains (1) summary
    pfam15991
    Location:5292
    G_path_suppress; G-protein pathway suppressor
  2. NM_019726.5NP_062700.2  G protein pathway suppressor 2

    See identical proteins and their annotated locations for NP_062700.2

    Status: VALIDATED

    Source sequence(s)
    AL596185, AW046264, BC138880, CJ092297
    Consensus CDS
    CCDS24922.1
    UniProtKB/Swiss-Prot
    Q921N8
    UniProtKB/TrEMBL
    Q9WV81
    Related
    ENSMUSP00000054072.6, ENSMUST00000057884.6
    Conserved Domains (1) summary
    pfam15991
    Location:5292
    G_path_suppress; G-protein pathway suppressor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69804805..69807882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246187.2XP_030102047.1  G protein pathway suppressor 2 isoform X1

    Conserved Domains (1) summary
    pfam15991
    Location:5292
    G_path_suppress; G-protein pathway suppressor