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Metap2 methionine aminopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 56307, updated on 5-Mar-2024

Summary

Official Symbol
Metap2provided by MGI
Official Full Name
methionine aminopeptidase 2provided by MGI
Primary source
MGI:MGI:1929701
See related
Ensembl:ENSMUSG00000036112 AllianceGenome:MGI:1929701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p67; Amp2; Mnpep; p67eIF2; 4930584B20Rik; A930035J23Rik
Summary
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 47.5), liver E14.5 (RPKM 37.1) and 20 other tissues See more
Orthologs
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Genomic context

See Metap2 in Genome Data Viewer
Location:
10 C2; 10 48.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93694351..93732952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93858489..93897090, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloexopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloexopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid modification ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-methionine modification ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methionine aminopeptidase 2
Names
MAP 2
eIF-2-associated p67
initiation factor 2-associated 67 kDa glycoprotein
initiation factor 2-associated protein (p67)
metAP 2
peptidase M 2
NP_062622.1
XP_006513959.1
XP_006513960.1
XP_017169521.1
XP_036011787.1
XP_036011788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019648.3NP_062622.1  methionine aminopeptidase 2

    See identical proteins and their annotated locations for NP_062622.1

    Status: VALIDATED

    Source sequence(s)
    AC124686, AF434712, AK165301
    Consensus CDS
    CCDS48673.1
    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Related
    ENSMUSP00000138006.2, ENSMUST00000180840.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93694351..93732952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513896.4XP_006513959.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513959.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  2. XM_017314032.2XP_017169521.1  methionine aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q3UI33
    Conserved Domains (1) summary
    PTZ00053
    Location:106477
    PTZ00053; methionine aminopeptidase 2; Provisional
  3. XM_006513897.5XP_006513960.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513960.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Related
    ENSMUSP00000138083.2, ENSMUST00000181217.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  4. XM_036155894.1XP_036011787.1  methionine aminopeptidase 2 isoform X1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  5. XM_036155895.1XP_036011788.1  methionine aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q3UI33
    Conserved Domains (1) summary
    PTZ00053
    Location:106477
    PTZ00053; methionine aminopeptidase 2; Provisional